In the town of Wendell cats and humans can have conversations, and Buckley and Eddie are two feline friends who are no exceptions. But that's where their talents end. When they aren't roaming the town with no particular destination, they are lazing around the house mooching off their owners' hospitality. See what kind of trouble they can drum up in this ABC Family series.
Buckley and Eddie want to take a vacation in Mexico, but when they are unsuccessful in boarding the airplane, they decide to simply pretend that they are in Mexico. Meanwhile, ignored and in search of a friend, Tabitha brings home the corpse of a cat that died on the freeway.
Buckley tries to organize the neighborhood against a developer who is going to despoil the natural beauty of the woods. The main problem is that Trevor, the developer, is Louise's new boyfriend. Buckley also tries to find a way to re-attach Tabitha's ear, which he accidentally ripped off in a fight.
Louise asks Buckley to clear the basement of rats. The only problem is that Buckley is too chicken to do so. That is until he meets 'The Big Guy' (who turns out to be a tiger) and he tries to copy everything the tiger does.
When Buckley finds another man in Louise's bed, he decides that it would be best to have a new name and leave town.
In order to get Louise a nice birthday present, Buckley is going to need to do something to get the money fast (Even if it means selling Tabitha to a science lab).
Buckley has made a huge mistake! Not only did he falsely believe that Eddie killed himself, he also ends up ending his own life. It's a good thing that cats have 9 lives.
Dolenz is released from the pound and goes after Buckley from putting him there.
Eddie's master is forced to have Eddie neutered when he finds out how many kittens he's had. Buckley attempts to rescue him.
Buckley is framed for murder when an old friend returns.
Buckley, Eddie, and Tabitha are trapped in the garage and get caught in a love triangle.
After Buckley and Eddie get Louise fired, Buckley attempts to get her job back with unintended consequences.