The show follows the exploits of Sol Butcher, Ricky Butcher, and Doug Borski, who operate a successful butcher shop called "Sons of Butcher Quality Meats" in the slums of Steeltown, a city modelled after Hamilton, Ontario. When not tending to the shop, they play together at various venues in a Rock band, naturally called "Sons of Butcher".
When Sol and Ricky's father falls into the meat grinder, they are faced with a dilemma: pursue Ricky's rock n' roll dreams, or follow Sol's vision to continue the family butchery business. Doug struggles to become a man after botching his rite of manhood firewalk.
Sol needs fresh meat for his Stewfest entry, Ricky seeks to hide out from his girlfriend's angry brother, and Doug hopes to get rich by finding Bigfoot, so they all head into the forest. Sol befriends his prey, Ricky becomes one with nature, and Doug challenges Bigfoot to a rousing game of Jenga.
Ricky achieves his rock n' roll dream by getting signed to a major label, however, as part of the rival band Feedbag. After knocking a woman off a bridge, Sol plunges into alcoholism. After getting mugged, Doug takes martial arts and becomes a bouncer.
After coughing up his balls, Sol gives up butchery for a less manly job - the construction union. Ricky and Doug search for the biggest boobs in the world, and end up at the circus. There Doug confronts the lion that ate his parents, and Ricky gets a job washing the fattest woman in the world.
After nearly getting killed by angry husbands, Ricky settles down with a mail-order bride. Needing help around the shop, Sol orders an exchange student to exploit. Doug's worried he'll lose his job, and in a fit of jealous rage he destroys Sol's guitar by accident.
The government is about to seize the family cottage, and Ricky is under doctor's orders to take it easy after a heart attack, so the boys head up north for one last weekend. Sol tries to save the cottage by entering a fishing derby, Ricky tries to lose weight with a tapeworm, and Doug persues fame and fortune by faking a UFO sighting.
Dreaming of breast augmentation (for himself) Ricky loses the shop in a low-stakes poker game. He enters a big money butchery contest to try and win it back, but is kidnapped before he can compete. Sol beaks his finger recording a secret song for Ricky, so he's forced to train Doug to finally become a butcher.
Sol orders an anteater for a new ship promotion, but receives a crate of refugees instead. Ricky and Sol are arrested for smuggling humans and thrown in jail, and Doug is left alone to run the shop with the help of his new refugee friends. Ricky and Sol complete in jail for the attention of the other inmates, and Doug learns that a pack of refugees can be as annoying as a girlfriend.
Doug finds a possessed porn magazine at a library book sale that sucks the souls of its readers. Sol caters a funeral and, after spicing the meat with zombie ash, creates and controls an army of the undead. Ricky gets his soul sucked by Doug's satanic porn magazine, allowing him to write a prodigal hit song, which he sells to a major label.
Sol gets sucked into buying a timeshare in the Middle East, and flees there after being accused of stealing things all over town. Ricky forms a vigilante group to hunt and kill his brother, while Doug creates a charity to try and pay the rent.
After a fire in the shop, Doug is forced to attend a fire safety seminar, where he falls in love with a really old lady. Sol, left alone, must cover for Doug, but struggles with simple cleaning techniques. Tired of getting stiffed at gigs, Ricky finally lands a paying show - and botches the address.
Ricky gets suckled by pigs after a car accident with a farm truck, throwing his manly rock god status into serious jeopardy. He then seeks to restore it by suing the pig farmer. Sol teams up with a local poacher and sells endangered meat to help fund the case. Doug befriends a dog, and learns to lie to impress women.
Sol and Ricky pursue the woman of their dreams on a cruise ship - the same woman. Sol attempts to crush coal into diamonds to impress her, while Ricky goes on steroids. After spotting his infomercial idol on board, Doug tries to sell him on his fabulous braided mop technique, the "Rehydrator."