The show follows the exploits of Sol Butcher, Ricky Butcher, and Doug Borski, who operate a successful butcher shop called "Sons of Butcher Quality Meats" in the slums of Steeltown, a city modelled after Hamilton, Ontario. When not tending to the shop, they play together at various venues in a Rock band, naturally called "Sons of Butcher".
After the government slates the shop for demolition, the boys hit the nearest Native Canadian Reservation to get 'fake proof' that the shop is built on sacred Native burial grounds. While on the 'Rez', Doug becomes a medicine man in fear of the 'chicken fever', and Ricky puts on a rock show for the hostile youth.
Doug, after being arrested for buying concert tickets illegally, is forced to go undercover and infiltrate the world of Nick Kiedis, Steeltown's biggest ticket scalper. Ricky and Sol attend a rockin' concert, but Ricky's full-body rash and Sol's pee shyness threaten to ruin their fun.
The boys meet their #1 fan, a goofy kid named Friso. Sol uses Friso's dirt-bike skills to lure customers to the shop, and Ricky feigns friendship with Friso to get close to his promiscuous single mother. Doug has an accident and struggles to cope with his resulting disability, and is duped into acting as a drug mule.
After reading his fortune, Doug discovers he has 12 hours to live. Ricky uses the news as a way to score the band a spot on Jaco's benefit concert, while Sol decides to build a robotic janitor to replace Doug.
Ricky, after beating local angry Greek man Jaco in a fight, piledrives his way into the world of pro-wrestling. Culture and tradition collide when Sol must also fight Jaco, only it's a battle for the heart of Jaco's beautiful daughter Suncheeps. Meanwhile, Doug learns the practicalities of a sewing kit when he becomes Ricky's secret guardian angel.
Sol has an epiphany whilst delivering a baby calf, and promptly gives up his life as a butcher. As he is sucked into a life of deadly Veganism, Sol's mental and physical health deteriorate rapidly, and he really starts to look like hell. Ricky and Doug seek to promote the band by creating violent makeshift rockets, which do a lot more harm than good.
Ricky is sweet talked into a recording deal with a local producer who later turns out to be a maniacal song-stealing killer. Sol turns the shop into a haunted house attraction which becomes possessed by his dead father’s ghost.
Ricky thinks band merchandise is the last step in achieving rock stardom, so he quits the shop for a higher paying job at the local Steel Mill. Doug creates the ultimate marinade unknowingly using marijuana as a key ingredient while Sol fears he may have a touch of the Gonorrhea.
When Doug delves into the world of role playing games Sol fears he may have joined a cult. Seeking advice from a priest, they attempt an intervention only to discover that Ricky is actually the one dabbling in satanism. After an exorcism and some light hypnosis, Ricky becomes a born again Christian while Sol second guesses his decision to get the church involved with family business.
Ricky takes advice from a metrosexual womanizing playboy, and changes his look and approach to women, in the hopes of finally scoring. Doug lands a role in a major motion picture event, and Sol sells meat on credit to some dirty bums.
Sol and Ricky accidentally become stars in the world of musical sex education, but Sol's enthusiasm for his craft lands him in some hot water with local authorities. Doug, while trying to leave porno behind and find a nice girl, actually ends up starring in an adult film. It's Sol's chance to redeem himself when he and Ricky rush to stop Doug from doing something he'll regret forever.
When the boys get caught parking in a handicapped spot, they each offer a bizarre justification to the by-law officer, including space travel, sharkmen, the Olympics, and a giant lactating stripper.
After experiencing all the tell tale symptoms, Doug believes he's pregnant. Sol, desperate for a way to beat competitor MEATCO's newest cut of meat, believes Doug's miraculous conception can only mean that the Messiah of butchery is on the way to bring him the answer. Meanwhile Ricky meets the women of his dreams and struggles to deal with her three children.