Taking place during the mid-22nd century, the crew of the first warp five starship (the Enterprise NX-01) begin to explore the galaxy under the command of Captain Jonathan Archer. As their mission progresses, the crew encounter familiar races like the Klingons and Andorians as well as some new ones.
Captain Archer and his crew set out to gain information about the mysterious and antagonistic Xindi race.
Enterprise starts experiencing effects of the spatial distortions pervading the Delphic Expanse, and falls victim to predatory aliens.
On a mission to investigate an abandoned Xindi vessel on a jungle planet, Archer, Reed and Hoshi succumb to a virus that mutates them into a primal life form.
The NX-01 gets closer to a showdown with the Xindi when Captain Archer takes on an enigmatic passenger: a beautiful slave named Rajiin.
When Enterprise responds to a distress call from a Vulcan ship stranded in the Delphic Expanse, Archer and his boarding team are attacked by insane zombie-like Vulcans.
A powerful telepath makes contact with Hoshi and offers to help Enterprise find the Xindi ... for a price.
Archer, Reed and Major Hayes infiltrate a Xindi-Sloth industrial colony to learn more about the weapon of mass destruction that will be used against Earth.
A spatial distortion leaves Archer unable to form any new long-term memories. Years in the future, he wakes up one morning and is stunned to learn the outcome of the human-Xindi conflict.
When a settlement of humans living a 19th-century Western lifestyle is discovered on a Delphic Expanse planet, Archer and crew set out to learn how they got there.
When Trip suffers a catastrophic injury, his only hope for survival is a transplant from a "mimetic symbiont" which Phlox grows from one of his exotic creatures.
Archer and T'Pol travel back in time to 2004 Detroit to stop a Xindi plot.
Religious zealots hijack Enterprise to use it as a weapon against the enemies of their faith.
An Andorian ship led by Commander Shran arrives in the Delphic Expanse to help Enterprise hone in on the Xindi super-weapon.
Archer finds himself face-to-face with Degra, the designer of the Xindi superweapon, and tries to get him to reveal its location.
As Archer tries to unravel the mystery of a rescued alien, long-simmering feelings explode among his senior officers.
The fate of Enterprise is in Dr. Phlox's hands as the rest of the crew must be induced into a coma in order to survive a trans-dimensional disturbance.
Archer goes to extreme lengths to save an abandoned nest of Xindi-Insectoid eggs ready to hatch.
Archer sets out on a suicide mission to destroy the Xindi superweapon as Enterprise faces a brutal attack.
While dissension among Xindi ranks festers, Enterprise tries to recover from a devastating attack.
Two high-ranking Xindi offer to stop the launch of their superweapon if Archer can prove they've been manipulated. Meanwhile, the crew mourns their lost mates.
An attempt to use a Xindi subspace corridor leads the Enterprise crew to a bizarre encounter with their own descendants.
Archer and Hoshi stand before the Xindi Council as T'Pol and Reed lead a team into the heart of a Sphere.
With help from Xindi allies, the Enterprise crew attempts to stop the arming of the Weapon aimed toward Earth.