Kirsten is recruited into a covert government agency to be 'stitched' into the minds of the recently deceased, using their memories to investigate murders and decipher mysteries that otherwise would have gone to the grave. Working alongside Kirsten is Cameron, a brilliant neuroscientist whose passion for the program is evident in his work. The secret program is headed by Maggie, a skilled veteran of covert operations, and includes Linus, a socially immature bioelectrical engineer and communications technician. Kirsten's roommate, Camille, a gifted computer science grad student, is also recruited to use her skills to assist Kirsten in her new role as a 'stitcher.'
Kirsten Clark’s life lays in the balance as the Stitchers team works to bounce her back into the real world after she became trapped in a stitch attempting to find her mother. Fueled by his love for Kirsten, Cameron finds a way to bring her back to reality, but it could cost them their relationship. Meanwhile, the Stitchers lab is on lockdown, leaving an anxious Linus unable to check on his father’s condition after surgery. But, as the team prepares to be reassigned for breaking protocol, NSA Director Mitchell Blair surprises everyone by demanding an emergency stitch that yields shocking new information.
The Stitchers team investigates the case of a young woman found dead in her wealthy boyfriend’s pool. Meanwhile, Linus feels a connection to Ivy, Cameron has growing concern for Kirsten’s emotional vulnerability and Camille is intrigued by an attractive medical examiner who likes to meet in unusual places.
A high-profile divorce attorney is murdered and the Stitchers team must sort through a plethora of suspects. Meanwhile, Linus discovers the cause of the neurosync issues in the stitches, which directly affects Kirsten and Cameron.
When an MI6 agent is found dead, Kirsten struggles to sort through his memories due to the visual codes that the spy used to keep secrets. Meanwhile, Linus and Camille go on a double date, but not with each other.
Cameron’s estranged father, currently serving time in prison for white-collar crimes, is accused of murdering a prison guard. Going against protocol, Kirsten stitches into the guard’s memory for clues.
After an engineer ends up dead, his colleague and work rival becomes a suspect. However, upon examining some stitches, Kirsten and the team uncover that he was a part of an underground gaming club. The team must juggle saving a falling satellite while Cameron takes a walk on the wild side when he infiltrates the gaming ring to get close to another suspect.
When Kirsten wakes up to find that everyone in the stitch lab, except Cameron, is missing, the two search everywhere but only find a series of mysterious clues. Eventually Kirsten realizes that she's still stitched into an autistic man with unique empathetic abilities. Kirsten is forced to confront her own emotions about her relationship with Cameron and unlock a memory in the victim's mind to bounce back
The Stitchers team investigates the murder of an ex-Air Force officer who is found murdered by what seems like a UFO, and the trail leads to a former co-worker and renowned UFO expert. The memories in the stitch have the team wondering if UFOs and extraterrestrial beings really exist.
A series of murders, including a professional volleyball player, lead the Stitchers team searching the darkest corners of the Internet. Meanwhile, Kirsten gives Maggie an ultimatum.