Col. Guile, Chun-Li Zang, Charlie Blanka, Ken Masters, Ryu Hoshi and others form an elite group of street fighters from all around the world to combat General Bison and his henchmen, attempting to stop his evil dreams of world domination.
Needing the help of the Street Fighters, Dhalsim summoned them to his remote mountain temple by causing Blanka considerable mental pain. It seems that the Satin Hammer had returned and wanted to steal an atomic bomb that Dhalsim currently had in his possession. Guile brought Blanka, T. Hawk, and Sawada along with him for the mission, even though personal feelings still existed between T. Hawk and the Satin Hammer. Eventually, the Street Fighters stopped the Satin Hammer's plot when Dhalsim deactivated the atomic bomb's countdown timer.
A crime wave has taken over London, and Bison is thought to be the one responsible for it, so Guile, Cammy, and Honda join forces with the team at MI5 to take down Bison, Birdie, and Sodom. During the fight, Bison seemingly takes over Cammy's mind, and she immediately switches allegiances. With a backup plan in full readiness, Bison and Cammy manage to escape.
Chun-Li is attacked by mysterious mutant assailants, as well as having her TV crew kidnapped. She calls for Guile and Blanka's help to track them down, which leads to a search in the sewers. They soon find out that a former scientist of Bison's is continuing mutant research and mutated 3 thugs into half-man/half eel/alligator/bat warriors. In the ensuing battle, Blanka receives a mega-dose of mutagen ooze, which turns him even more feral.
While visiting their master Gouken, Ryu and Ken are challenged by the evil Akuma, who claims to have stolen Gouken's chi and will do the same thing to them. Akuma gives Ryu and Ken time to train so they might stand a chance against him. During the course of their sparring sessions however, Ken injures Ryu's right arm, which leaves Ryu in a bad state during the time of the fight's progression. Akuma uses this advantage to easily defeat Ryu, only to get defeated himself by Ken's Flaming Dragon Punch (Shoryuken), freeing Gouken and Ryu's chi. Despite his apparent defeat, Akuma vows that he'll return and attempt to steal more chi.
Ryu and Ken are asked to help Fei Long with his latest movie project. Investors in the film however pull funding from out of the movie, which leaves Fei Long with no way to raise awareness about the evil crime boss, Lo Fat. Ken is forced to ask his father to re-invest in the film, so it can continue. Ken gets creative license for the script, and writes himself in as the star instead of Fei Long. Both men have a climatic showdown which results in the entire movie studio burning down.
Guile and Blanka take a trip to the Middle East to cool hostilities between the Arabs and the Israelis, but Blanka's temper gets the best of him, and he attacks them all. Vega, watching this drama unfold on a prison TV set, swears revenge against Blanka for destroying his face. Vega easily escapes, and flies to Hawaii for a final battle while taking Mei Lei, Blanka's love interest, hostage. Blanka almost manages to kill Vega, but with the combined efforts of Mei Lei, Guile and Chun-Li, they were able to prevent Vega's death at the hands of Blanka.
Bison charges Cammy and his cybernetic creation La Lupa to steal a priceless Kali statue for him. The statue has meditative powers that Bison hopes will help him heal his wounds from his previous battle with Guile. The Street Fighters team up with MI5 to help get to the bottom of Cammy's switched allegiances and during the battle, Cammy gets knocked on the head which frees her from Bison's mental control. Cammy then takes the Street Fighters to Bison's hideout, where she betrays them once more. Bison and Cammy are then able to escape.
The mystical psychic known as Rose senses that many powers in the world are fluctuating wildly out of control. She blames Ken and Blanka for this sudden energy spike and believes that they are the catalysts to the end of the world. Rose kidnaps them both and forces them to fight against one another, only to realize that they are not evil at all. With their help, she tracks down Bison, who is the true manifestation of evil she had sensed. She then attacks Bison in the mental world just as Ken and Blanka destroy the kali statue, which destroys Bison's entire castle. Mysteriously, everyone in uninjured, and Bison eludes capture once more.
The powerful Warrior King has defended his country from the evil Mages for years, but when his Orb of Power is flung into a vortex, he follows it as well. The orb lands in a nation close to Shadaloo, and Bison claims it as his own. The orb has the power to control all weather, and Bison threatens the world with its power. The Street Fighter team is assembled, and Chun-Li is the first to confront Bison. The Warrior King magically appears, and fights Bison's minions with Chun-Li's help. The two quickly fall in love until another vortex appears, and the Warrior King is forced to leave Chun-Li forever. This episode is a crossover with Savage Dragon, Wing Commander Academy and Mortal Kombat: Defenders of the Realm animated television series (1996, US).
Blanka searches the jungle for a mysterious healing plant that could revert him back to his normal form. Guile and Lucinda go to track him down, and hear the same story of the plant from the jungle natives. Blanka then encounters a wild jungle boy who swears revenge against the natives for killing his family. The boy is actually an alien who had crash-landed on Earth along with his family. Blanka befriends the boy, and along with Guile and Lucinda, they defeat the evil natives and the boy returns to his home planet.
Ryu is a legend in Shadaloo and Sakura is his most adamant admirer, but when Sagat patrols the streets regularly making sure to burn down any building with posters of Ryu in it, Sakura leaps into action. She has gone to New York (not shown) to go see her idol, who had just been visiting Ken in the hospital, as Ken had swallow some bugs in water while fighting Ryu earlier. Ryu meets Sakura, and she convinces him to come to Shadaloo along with Guile, to defeat Sagat once more. Sagat welcomes the challenge, and he and Ryu have another epic confrontation.
The plot of this episode is based on the arcade game with the same title. The new Mayor of Metro City, Mike Haggar, finds himself in a tough situation when his daughter Jessica is kidnapped by a ruthless street gang known as Mad Gear, so it's up to Ryu and Ken to save her, along with Jessica's boyfriend Cody and fellow friend Guy (despite the fact that in the arcade game, Mike Haggar goes out to rescue his daughter with Guy and Cody). Escher, Guile, and Haggar devise a plan to put Ken and Ryu undercover to infiltrate the gang and discover the whereabouts of Jessica, but Cody takes exception to this as he constantly screams at everyone in protest, nearly jeopardizing the entire plan. The four fighters encounter the Mad Gear gang's leader, Belger from within the group's headquarters and an intense fight happens. Ryu and Ken, along with Cody and Guy, are able to fight against Belger and his minions and in the end, the quartet defeats Belger and saves Jessica from complete danger while Haggar himself enters into the situation at the very end by breaking a door down.
Bison captures the MI5 team in a brief battle and the British government are adamant about getting them back, as they know critical government secrets. Bison compiles doomsday codes, which are the launch protocols for every known nuclear bomb on Earth, and plans to not take over the world, but to destroy it. Guile and Chun-Li are given a package from Sagat, containing the secret of Cammy's past, as Sagat does not want the world destroyed by Bison. They infiltrate Bison's base, and everyone, including MI5, team up to stop Bison, and destroy his computer console with one second left on the doomsday timer. Bison dies when he is consumed by the computer. Afterward, Cammy rejects Guile's offer to return to the team, opting to go on her own path.