These new adventures featured appearances by the core group of the five classic Super Friends (Aquaman, Batman, Robin, Superman and Wonder Woman) along with Zan, Jayna & Gleek. A 1981 episode titled "Evil From Krypton" depicted the Superman's Fortress of Solitude with a somewhat crystalline exterior and without the giant key, reminiscent of its film appearances. There were also guest appearances from members previously depicted in Challenge of the Super Friends as well as the original Hanna Barbera created hero El Dorado (debuting in the second season), who was added to the show to make the Super Friends more culturally diverse.
Apache Chief, Batman, and Robin face great danger when attacked by Bigfoot creatures.
The Wonder Twins and two other kids get trapped deep within the ski slopes. Meanwhile at the snow lodge, Clark Kent and Lois Lane are investigating a mysterious Ice Monster story. Clark sees the teens in danger and comes to their rescue as Superman.
Bud, a fed-up make up artist for a movie studio, decides to redo a monster mask for a government film using his untested hormone solution. As the unsuspecting make up artist puts on the monster mask, the experimental hormone solution reacts strangely with his skin, changing him into the very monster he created. The Flash, Batman and Robin, who were in the studio supervising the government film, encounter Bud and dare to challenge his reign of terror. The Flash points out the only way to stop Bud is to counteract the make up formula. Batman agrees and comes up with a formula using some material from the Batmobile. When the heroes turn Bud back to normal, the director offers them a contract to star in his next film. However, Batman points out that they already signed a lifetime contract with the Justice League.
While monitoring the galaxy from his impenetrable Fortress of Solitude, Superman notices a Black Hole that is going to suck up the Earth. Superman attempts to stop it but gets himself pulled into the Black Hole. Using the Bat-Rocket, Batman and Samurai set out to accomplish what Superman failed to do. However, the two heroes end up getting pulled into an Asteroid Planet in the center of the Black Hole. Upon finding Superman imprisoned, the heroes are attacked by a Star Energy Creature. The Super Friends must break free and stop the Star Creature from absorbing the Earth.
The Highway Angels, a motorcycle gang, start tormenting a senior citizen and his grandson. When the Wonder Twins try to help they have a hard time dealing with the cycle gang and the danger at hand. Wonder Woman sees the twins and gives them assistance.
Several miles off the coast of Hawaii, a routine Navy mission becomes a nightmare when a submarine's controls short circuits and the nuclear reactor starts to overload. Black Vulcan and Aquaman try to help, but are attacked by nuclear mutated sea creatures. Black Vulcan actually gets eaten by a mutated whale in which Aquaman must come to his rescue. When the two heroes get free, they make it aboard the submarine whose communication transmitter went dead. Now their only chance is to launch Aquaman out of a torpedo tube to clear the beach while Bluck Vulcan uses his electrical powers.
A group of archaeologists accidentally releases Yuna the Terrible and her barbarian warriors. Batman and Robin responds to a distress call but get captured by Yuna's warriors. Wonder Woman and Apache Chief respond to the Batman's distress call. During an encounter with Yuna, Apache Chief gets put into a trance and joins Yuna and her warriors. Wonder Woman tries to save them and must prove her strength against Yuna.
A group of Rock and Roll Space Bandits paralyze the Super Friends and invade a major city on Earth using their hypnotic music. The Wonder Twins come to the rescue but get hypnotized. Wonder Woman helps the rest of the Super Friends get free and they rush off to stop those musical menaces.
Streaking in the Invisible Jet, Wonder Woman and The Atom answer a distress call on the emergency scanner from a Dr. Wells. Wells' call was actually a trap to get Wonder Woman and The Atom to test out his new time machine. Wonder Woman starts pressing buttons attempting to escape but actually starts the Time Machine to send The Atom and herself to December 1776. General George Washington mistakes Wonder Woman for a spy and attempts to capture her. The two heroes escape and move further back into the past to a 17th century galleon where they are confronted by Black Beard. After saving The Atom, Wonder Woman and Atom escape in the time machine. The Atom decides to shrink down to microscopic size to rewire the circuits in the time Machine to go back to 1980. When they come back Dr. Wells tries to elude them by using the Time Machine to escape. The heroes travel millions of years in the Pre historic past to capture him.
Green Lantern and Superman must stop the reign of terror caused by Martians who traveled to Earth in a returning space probe.
A group of teens dare each other to go into the old Brimstone Mansion in the cemetery, a place that is said to be haunted. Two of them go in the mansion and get trapped inside. The other two ask the Wonder Twins go inside to look for the other boys but get captured by old man Holmes, the cemetery caretaker. Gleek informs Batman & Robin who come to the rescue and stop Holmes cold in his tracks.
Not for off the Alaska coastline, millions of gallons of crude oil spill out from a ruptured supertanker. Suddenly the crude oil comes alive in the form of a giant monster. Aquaman sees the monster and helps the supertanker to stop the creature by using a harpoon with a net wrapped around to contain the monster. When that plain did not work, the captain called the other Super Friends while Aquaman handled the monster. Hawkman and Hawkgirl arrive, but by the time they got there the oil monster had already taken off to the coast. Later, the oil monster attacks the Alaskan pipeline and grows even larger. Hawkaman and Hawkgirl try to stop the monster but they get covered in oil and get captured and eaten by the monster. Aquaman acts fast and saves the winged avengers by going inside the monster and using his telepathy powers as a radar. After Hawkman gets an idea of how to stop the monster, the three heroes go to a small general store to get all of the detergent soap so they can put the plan in motion. They arrive at the nearby harbor to find the monster feeding on the first storage tank. Aquaman leads the monster to the empty storage tank while Hawkman and Hawkgirl pour the detergent on the monster turning it back into plain crude oil.
Vampiress, the Voodoo Vampire from Africa, goes after the Super Friends and seeks to make them her vampire slaves. It's now up to Wonder Woman and Black Vulcan to go her underground tomb and stop her.
A group of Exxorian monkeys arrive on Earth to invade the Planet. The monkeys want to destroy the Super Friends by putting Gleek under their control. The Wonder Twins must use their powers to help Gleek and the Super Friends.
The Super Friends try to destroy each other as the impy villain Mr. Mxyzptlk strikes again!
The Super Friends respond when the moon cracks open, revealing a gigantic destructive bird.
While at the circus, the Wonder Twins and Gleek witness the revenge of circus animals as they zap the audience in a trance. The animals capture Gleek and zap the Wonder Twins as well, who they send off to lure Superman and Wonder Woman into a trap at the circus. The circus animals eventually turn the Super Friends into Super animals. Gleek frees Zan and Jayna from the trance, now it's up to the Wonder Twins and Gleek to free Superman and Wonder Woman and to end to this circus once and for all.
Superman brings a new engine for the Bat-jet to the Bat-cave. However when Batman opens it up he finds the Riddler hiding inside. He hops out and spritzes Superman, Wonder Woman, Batman, and Robin with stupid spray. There's only one antidote and the Riddler has hidden it somewhere and if the Super Friends do not find it before the time limit is up they will be super stupid forever. Before he hops away, the Riddler gives the Super Friends their first Riddle clue. The Super Friends arrive at the Mayan ruins in Chichen Itza, there Superman spots what he believes is the antidote in the pyramid by using his X-Ray vision. The Super Friends enter the pyramid only to be caught in a Riddler trap. They escape the trap they find the Riddler's second clue but by that time they need the assistance of the Bat-Computer because they had become too stupid to figure out the riddles. The computer tells them to go to Mt. Everest and there they defeat the Riddler and get the antidote.
First, the Super Friends must find a way to halt an unstoppable invasion of destructive "Termites From Venus."
The Wonder Twins rescue a group of reckless hangliders who fell into a volcano. Soon after the volcano starts erupting. Jayna calls Batman & Robin, who help the Wonder Twins rescue the rest of the town and stop the lava flow.
Hundreds of miles of the coast of North America, a routine Trans-Atlantic trip turns into a nightmare when a ship gets caught between some jagged rocks and takes on water. Aquaman was in the area assists by using his telepathy to summon two giant Manta Rays to seal the whole as he pushes the ship out of danger. As he attempts to head back to the Hall of Justice, a larger island arises from the sea. Aquaman recognizes it as the Lost Island of Ancient Atlantis (not to be confused with Aquaman's home in modern Atlantis) that has thought to been destroyed thousands of years ago. Upon checking out the island, Aquaman is captured by female Atlantean Warriors who seek world domination. The U.S. Coast Guards who were on the ship Aquaman saved send a distress call to Wonder Woman and Rima about an island moving towards shore. Meanwhile the Atlantean Warriors arrive at Washington D.C. and attacks the Army. Wonder Woman and Rima arrive and are confronted by Ocina, Queen of Atlantis, and are offered to join the group of Warriors. When the two heroes refuse they are captured and put in the water dungeon where Aquaman is. Wonder Woman uses her telepathic mind line to summon help from her mother Hippolyta and The Amazons of Paradise Island. The Amazons of Paradise Island travel to Washington DC to fight an epic battle against these femme fatales.
When an evil computer takes control of Gotham City's electronic equipment, the Super Friends must find a way to stop "The Killer Machines."
Next, a professor creates a "Garden of Doom" when he accidentally transforms ordinary tomatoes into huge, man-eating plants.
Bizarro takes revenge on the JLA by turning members into 'Super Bizarro slaves' and exposing Superman to Red Kryptonite. The Red Kryptonite's horrible effects cause Superman to grow extra arms and legs. Now Superman's only chance to stop Bizarro and return to normal is Blue Kryptonite.