The story revolves around two brothers, Sam and Dean Winchester as they follow their father's footsteps, hunting down evil supernatural creatures such as monsters, demons, and even fallen gods while trying to save innocent people along the way. Continuing the "family business" after their father's death, the brothers soon discovered that the "hunt" doesn't just involve slashing and hacking monsters and demons but also dealing with more powerful creatures such as angels, reapers, and even Death.
Sam enlists everyone’s help in trying to track down Dean, who can literally be anywhere. Meanwhile, Castiel may be in over his head after meeting up with an unreliable source. After being drained of his grace, Jack is adjusting to life as a human, learning new skills and figuring out how he fits in to this world of hunters.
Sam finds a clue to Dean’s whereabouts, so he, Mary and Bobby set out to investigate. Castiel imparts some sage advice on Jack, who, still desperate to belong, seeks out a familial connection.
Still trying to solve the mystery of what happened to Dean, Sam enlists the help of Sheriff Jody Mills who may unknowingly already be on the case. Castiel continues to be a father figure to Jack, who surprises even himself, when a life is on the line.
Dean continues to struggle. Meanwhile, Sam must think fast when action figures come to life, and our heroes find themselves living in a real-life horror movie.
After a hunt gone wrong leaves Maggie’s whereabouts unknown, Sam, Dean, Mary and Bobby race to find her, but what they find are their own worst nightmares.
Sam and Charlie team up to get to the bottom of a string of random disappearances. Meanwhile, Jack believes that he has found a case and convinces Dean to partner-up with him on the hunt.
Sam and Castiel track down a Shaman, who may be able to help a friend. Nick continues to spiral down a dark path as he looks for answers surrounding the deaths of his wife and son. Jack turns to Dean for help enjoying the human experience.
When Sam and Dean join forces with an unexpected ally, the outcome will alter the course of two lives. Meanwhile, Heaven faces an attack from a dark force, driving Castiel to make an enormous sacrifice to make things right.
Sam and Dean enlist the help of their pal Garth to gain inside information on what Michael may be planning. The brothers split up to each go after weapons that can aid in their fight against the Archangel, but this may be a fight our heroes cannot win.
Michael has re-taken control of Dean as his army of monsters continues to move in on our heroes. Sam devises a plan to try and reach Dean and stop Michael before anyone else has to die.
Dean spends some bonding time with Mary and Donna. Nick finally finds the answer he has been searching for. Sam is left to make an unimaginable choice.
Sam and Dean must figure out how to stop the bloodshed when Donatello, who, in his current condition, is inadvertently scrambling the order of future prophets. Nick comes face to face with his past.
Sam and Dean look to occult lore for a solution to their latest problem, but instead of a resolution, they find much more than either of them had anticipated.
Sam and Dean enlist the help of Rowena to track down a demi-god who feasts on human flesh; the challenge of keeping Michael at bay is proving to be more difficult than originally anticipated.
Sam and Castiel follow a case to a picturesque little town in Arkansas, only to find out nothing is as idyllic as it appears to be. Dean and Jack take a road trip to visit an old friend.
Sam and Dean are baffled when they come up against a monster they have never heard of before; Jack does his best to impress a new group of friends.
Sam and Dean race to help a friend in need. Meanwhile, Mary is concerned for Jack’s wellbeing, and Castiel enlists help from Jo/Anael to track down a miracle.
Sam and Dean continue to worry about the condition of Jack's soul.
Sam, Dean and Castiel investigate a string of suspicious deaths that have a biblical element to them.