Picking up here we left off last season, Sam, Dean and Castiel are left to defend the world after all the souls in hell have been released and are back on Earth and free to kill again.
Sam, Dean and Castiel call on Rowena to help keep the evil souls at bay and get an unexpected assist from Ketch.
Sam and Dean together with Rowena work tirelessly to keep all of hell from breaking loose. Castiel cannot forgive an arrogant betrayal.
Sam and Dean investigate the mysterious death of a girl and the disappearance of another.
Sam and Dean’s routine case turns out to be anything but.
Sam and Dean are visited by an old friend. Castiel investigates the disappearance of a local teen.
Dean goes off on his own to take on a case. Meanwhile, Castiel has an idea of how he can help Sam track down God.
Sam, Dean and Castiel’s continued search for a way to defeat Chuck leads them to unexpected places and toward unlikely allies.
Sam and Eileen are faced with the brutal truth. Meanwhile Dean and Cass work together in the hopes of getting a step ahead of Chuck.
Sam and Dean hit the road to help an old friend, but it appears that their luck may have finally run out and they are the ones who may be in need of rescue.
Sam and Dean press their luck in a winner-takes-all game of pool. Meanwhile, Castiel hunts down a would-be murderer, but not for reasons one might think.
Sam and Dean respond to a frantic call and together along with Castiel, Jack and Jody, assist in an extraordinary and heartbreaking rescue. Billie surprises everyone with a visit to the bunker.
A search for the one thing that may give the Winchesters an edge against God leads Sam and Dean to Jo’s door and to a secret that may have died with Ruby. Meanwhile, Castiel asks Jack to do the unthinkable to help the brothers in their quest.
Sam and Dean discover a wood nymph living in the bunker who is determined to protect her family, at any cost.
Castiel and Jack work a case involving members of a local church. Meanwhile, Sam and Dean go off in search of Amara.
Sam and Dean are asked to investigate the murder of a childhood friend, calling them back to a motel from their past and perplexing the brothers with a case they thought was solved a long time ago.
Dean hits the road with Jack who needs to complete a final ritual in the quest to beat Chuck. A difference of opinion leaves Sam and Castiel behind looking for answers to questions of their own.
With the plan in full motion, Sam, Dean, Castiel and Jack fight for the good of the common goal.
Everything is on the line as the battle against God continues. A familiar face returns to join the fight.