The Adventures of Jimmy Neutron: Boy Genius follows Jimmy Neutron, his faithful robotic dog, Goddard, and his eclectic friends and family as they experience life in Retroville. Jimmy is a typical kid, who just happens to be a genius. He creates gadgets to improve his everyday life, but his inventions go awry more often than not, and hilarious trouble ensues.
The gang enters a script-writing competition, where the winning script will get turned into a movie! The director, Quentin Smithee, chooses Jimmy, Cindy, Libby, Sheen, and Carl (much to Hugh's disappointment) to star in Jimmy's movie, which will be shot entirely in Retroville. During the filming, however, dangerous on-set "accidents" start to happen, and the rest of the kids start to doubt starry-eyed Jimmy and inexperienced Smithee.
An encounter with the Van Patten radiation belt causes strange mutations in the kids: Jimmy glows orange, Cindy is super strong, Sheen is super fast, Libby can become invisible, and Carl has sonic burps. As the N Men, they work to fight evil in Retroville, but they end up doing more harm than good. The military soon steps in, capturing four of the kids, but only laughing at Jimmy's orange hue. When Jimmy discovers the dark side to his friends' new powers, he must race against time to find a cure - and deal with the effects of his power.
Jimmy, Sheen, and Carl travel 15 years into the future, only to find that some things have gone wrong. Can they right the past to save their future?
After the car company Hugh works for decides they don't need his services anymore, the Neutrons are faced with the awful prospect of moving. To stay in Retroville, Hugh becomes a toy inventor, and the Nanobots return again to wreak more havoc....
A trip gone wrong ends up turning even worse when Jimmy and Cindy get into an argument that winds up getting them stranded together.
Jimmy becomes frustrated at school when his scientific lecture is disregarded in favor of making macaroni sculptures. So, when Dean Cain, head of Pamona University, offers him a chance to enroll in that college to help them win a science grant, Jimmy eagerly accepts. He soon finds, however, that college is a completely different world from elementary school ... a much more challenging one. And when it comes to jealousy of Jimmy's knowledge, Cindy (left behind at Lindbergh Elementary) doesn't hold a candle to new classmate Seymour.
Carl gets infected by a "face-hugging" parasite, and becomes pregnant with an alien baby.
Clash of the Cousins The Neutrons go to a little family reunion ... but all their relatives look like Hugh!
Beautiful Gorgeous and Jet Fusion are getting married!
A kung-fu warrior wants to be The Chosen One in the temple of Shangri-Llama, but Sheen holds that position, with his ability to put his leg behind his head. So, the warrior kidnaps Libby in order to fight with Sheen and claim the title of The Chosen One as his own.
Jimmy accidentally shrinks the town of Retroville. Can he get it back to normal size before they're crushed?
A children's show has hypnotizing powers and turns the town of Retroville against Jimmy.
Vanishing Act Jimmy tries to become a magician to impress Betty, but something goes horribly wrong, and he ends up transporting the group into alternate universes.
Evil Jimmy returns! Jimmy needs his evil clone to "be" him so he can up his invention output by staying in his lab while the clone goes to school and spends time with his friends and family, so he tries to make the clone a "Good Jimmy." Of course, things go wrong and Evil Jimmy wreaks havoc around town....
Jimmy travels to the Bahama Quadrangle (a parody of Bermuda Triangle) to solve the mysterious disappearances surrounding it.
Carl wants to impress a girl by making Jimmy seem stupid in comparison to him.
Who Framed Jimmy Someone's stolen a lot of money ... and the evidence points to Jimmy! Can Carl, Sheen, and Jimmy figure out who's framing the boy genius?
Flippy Hugh wants to become a ventriloquist, so Jimmy decides to give him a hand. But his modifications may cause a big problem for his father....
How to Sink a Sub Jimmy sends the teachers away for a week, so the parents decide to step in.
Lady Sings the News The kids become news anchors for a local television network. But Libby's gossip section soon proves to be horrifyingly embarrassing! Can the other kids put a stop to her before it's too late and all their secrets are revealed?
Eustace Strych is back, and he's still determined to humiliatingly defeat Jimmy. Now the race to find an energy source on Mars is on! Who will win?
El Magnifico Mr. Estevez wants to impress his son, so he asks for Jimmy's help.