Cathy seeks a second opinion, causing a strain on her relationship with Dr. Todd; Sean learns about his sister's cancer while adjusting to life with a pregnant Rebecca; Adam sees a therapist against his will.
Frustrated at not being able to land a spot in the clinical trial of a new treatment by a respected oncologist, Cathy resorts to supernatural aid; Sean becomes assertive around the house; Adam capitalizes on his classmates' sympathy about his mother's illness.
Cathy and Paul experience frustrations in bed and with the help of their new house mate Andrea, realize they need to set some patient-caregiver limits; Rebecca is put off by the newly medicated Sean; unsatisfied by his physical relationship with Mia, Adam turns to another girl, Emily.
Cathy is intrigued by Lee, a fellow cancer patient she meets on the first day of her clinical trial; Adam's downward spiral continues with a fight at school and refusal to take responsibility for his actions with Emily; Sean is worried that his new house is haunted.
Due to Paul's layoff, Cathy starts to pawn her jewelry and meets Lee there as well. Adam gets into a situation that he may need help with to get out of. Sean is kicked out of a mother's group when he tests out his homemade sling at the park
Adam's shocking indiscretion threatens Cathy's new job as a swim coach; sparks fly between Andrea and Myk, a Ukrainian coworker that Paul is mentoring; Sean seeks advice on taking the "next step" with Rebecca.
Lee takes Cathy to a Tibetan doctor to deal with her high blood pressure. Feeling jealousy of Lee, Paul takes Cathy and Lee out for an evening, while Adam interfere with Andrea's date.
Cathy invites friends and family to a Thanksgiving dinner, but a long-hidden secret she brings to light causes trouble.
Rebecca deals with the grief over her miscarriage in an unexpected way which leads Cathy to reconnect with old friends; Andrea's relationship with Myk heats up; Adam is taken by surprise when he finally meets the girl he's been chatting with in an online cancer support group.
Cathy helps Lee check a few items off his "bucket list;" Poppy takes Adam to her high school reunion; a distraught Sean takes issue with his new neighbors.
After an argument with Lee and a revealing dinner with Dr. Sherman, Cathy (Laura Linney) comes to a major crossroads. Elsewhere, Adam searches for his AWOL uncle and an impulsive Andrea makes a decision about Myk.
As Cathy prepares for her trip to Italy, she receives an amicable call from Lee. Elsewhere, Paul uncovers a secret about Myk while Adam discovers one about Poppy.