Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist".
Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.
While continuing to battle Berlin, Red faces a new threat in the form of Lord Baltimore. A figure from Red's past returns. Liz tries to move on after her showdown with Tom.
A robbery provides Red with an opportunity to take down a questionable bank. Liz questions Red's intentions during the course of her investigation. An impressive addition is made to Cooper's team.
When a body is found missing a heart, Liz and Ressler join forces with Samar Navabi to investigate Dr. Covington's operation. Red and an associate try to take advantage of an opportunity in Indonesia.
Red thinks a dangerous sociopsychological experiment may be taking place when several previously nonviolent citizens become killers. Red has a complicated proposition for Naomi and her husband.
The team targets an eco-terrorist cell seeking a deadly weapon. Liz attempts to lose her guardian. Red resorts to manipulation to pursue a special someone.
Liz asks Red for information about deadly wildlife poachers after a mutilated corpse washes ashore. Ressler forms a dangerous habit.
A plot for revenge emerges after an Iranian nuclear scientist is assassinated. Liz and Ressler wind up in a predicament.
Red’s motives for Berlin take a sudden turn when he learns Berlin was manipulated by the latest Blacklister to avenge Red. Red and Berlin travel to Moscow to track down a high ranking Russian official who they believe is responsible. Liz struggles to keep her secret from unraveling.
When Red is arrested and taken to a secret detention facility, Liz and the task force set out to save him before he disappears forever. At the facility, Red encounters a thief with whom he shares a complicated history.
As chaos ensues at the Factory, leaving the fate of Red and the task force unknown, Cooper struggles to rescue his team from the detention facility. It’s a race against time to prevent Luther Braxton attaining confidential information.
When an undercover CIA agent is kidnapped by a band of separatists in Uzbekistan, the task force sets a rescue mission in motion. Red informs Liz and Ressler that they are up against a very dangerous former associate.
When Red tips Liz off about the disappearance of a polygamous cult leader with dangerous shipping containers buried on his property, the task force sets out to investigate. Red utilizes his sources to appease Fitch’s last words and tries to track down his hidden safe.
Red helps Liz and the task force find a killer — the Deer Hunter — who tracks victims like prey. Meanwhile, the local DC police suspect the city Harbormaster was murdered as Liz struggles to keep her secret from unraveling.
A former paramour involves Reddington in a deadly game with a wealthy, powerful family dynasty whose ill-begotten fortune was amassed from an underground auction of human and material contraband. Meanwhile, Tom takes on a new mission.
When Agent Keen is questioned in court as a suspect in the murder of the DC Harbormaster, her unusual relationship with Red and their task force falls under scrutiny. Meanwhile, Red enlists Cooper and Ressler to locate “The Major,” a dangerous former associate who is key in keeping Liz out of prison.
As evidence mounts against Liz in the case of the murdered DC Harbormaster, a federal judge makes it clear to her that she will face severe criminal charges. Reddington and Ressler jump into high gear to exonerate Liz but the only solution is to find the recently vanished Tom Keen — wherever he may be operating in world.
The task force tracks a scientist who abducts disabled patients to conduct experiments on immortality. Now back in Washington, DC, Tom scrambles to save himself from new enemies.
The task force tracks a provocative female Blacklister, a frame-up artist who targets the wealthy elite. Tom pleads for Liz's help. Red pressures Liz for the Fulcrum, claiming it's now a matter of life and death.
As Red fights for his life, he pleads with Liz to track down Nicholas Caul — a mysterious figure from his past with knowledge of The Fulcrum. It's a race against time for the task force to locate Caul before Red's life is threatened again, while Tom proves helpful in an unexpected way.
After decoding the information that is embedded in The Fulcrum, Red is determined to stop the imminent threat. Meanwhile, the task force discovers that deceased bodies of Chinese-American women are being smuggled out of the country under false identities. Liz continues to search for answers about her past after discovering a picture hidden in Red's secret flat.
Following intel from Red, the FBI find themselves one-step behind the most dangerous Russian Assassin, Karakurt, an enemy on U.S. soil. To avoid catastrophe, Liz and Ressler meet with Russian Counter-Intelligence who offer insight not only on Karakurt, but also on the identity of Liz’s mother. Cooper finds himself in a compromising position.
Liz realizes she is being framed by The Cabal, forcing Red to use his connections to help her clear her name. As Cooper receives shocking news, Ressler, Samar, and Aram must decide who on the task force can still be trusted.