Deputy Police Chief Brenda Leigh Johnson (Kyra Sedgwick) is a police detective who transfers from Atlanta to Los Angeles to head up a special unit of the LAPD that handles sensitive, high-profile murder cases. Despite a tendency to step on people's toes, Johnson manages to convert even her strongest adversaries with her unique ability to get to the truth.
When a massive fire breaks out in Griffith Park, Priority Homicide is on hand to help. But when an unidentified dead woman's body is found in the center of the scene, Deputy Chief Johnson is doing a lot more investigating then directing traffic. Meanwhile, Brenda and Fritz are living in a small apartment and getting on each other's nerves.
Brenda and the team must determine if a murder was revenge or mere coincidence when a recently released murderer turns up dead, the victim of a hit-and-run.
As usual, Brenda's personal life isn't much better: she must deal with a recently incapacitated Fritz.
Brenda suspects something more than suicide when a high-school girl is found hanged in her bedroom; the investigation uncovers a ruthless sexual game being played at a private school.
A man wearing a surveillance wire is shot to death at point blank range in downtown Los Angeles; interpersonal relationships on the squad force Brenda into a corner.
Provenza and Flynn lose the evidence in an attempted murder case when Provenza's car is stolen; Pope is not happy when Brenda is forced to free the suspect and gives her and the squad 48 hours to retrieve the car, the evidence and the suspect.
When a 12-year-old disappears, Brenda must decide whether to treat him as a runaway or a missing person.
The entire squad searches for the person who shot Detective Sanchez's brother; the case is jeopardized by an overzealous detective and a leak within the department.
Brenda and the squad investigate the murder of a hair stylist; Brenda's parents stop in for a visit on their way to Alaska; Brenda's father wants to know when she and Fritz are going to tie the knot.
An FBI informant is the prime suspect in the deaths of two Tijuana police officers; Pope, Taylor and Brenda must deal with a public relations mess when a newspaper prints an unflattering story about Priority Homicide.
The newly renamed Major Crimes Division investigates the death of a teenager that may be related to a planned massacre; the squad searches for a bomb before it can explode.
Brenda and the team investigate an apparent suicide that the medical examiner believes was actually a murder; Brenda's parents are staying with Fritz and Brenda for a few days.
The body of a man who stole $3 million in diamonds is found in the trunk of a car; the condition of the body makes determining the cause of death impossible.
Brenda goes toe to toe with the tricky attorney of a man suspected of a brutal rape and murder. Going a few rounds to get to the truth, Brenda dukes it out with the lawyer who is just as clever in the ring as she is. Can she hang in there and get to the truth before the final bell?
Fritz's sister agrees to use her psychic powers to help the Priority Homicide Division resolve one of their cases, and while her abilities appear to help her understand how Brenda works, they don't seem to stop her from offering misguided advice.
Brenda and Fritz's attention is diverted by problems on the job even though their wedding day has finally arrived, and bad blood between the members of the Priority Homicide Division threatens to cause one of the officers to leave the department.