Accompanied by haunting memories of his service time in World War II, Dr Lucian Blake returns home to Australia after 30 years to take over his deceased father's medical practice. As he deals with his own personal loss and changed by his war experiences, the wry, personable doctor performs his other role as police surgeon with gusto. His unconventional and unpredictable manner unnerve some, but it becomes clear Dr Blake is ahead of his time in his use of forensic science, and in his own understanding of the human heart, to help solve murder mysteries in the country town of Ballarat.
Dr Blake returns from China and finds himself thrown straight into a murder investigation when the newly elected mayor of Ballarat is found dead at the bottom of the town hall steps.
Doctor Blake must unravel the murder of an up-and-coming rock'n'roll star, after he collapses in front of his fans at a sell-out performance.
Doctor Blake struggles to discover the identity of an unknown man and uncover the mystery of who may have killed him.
Two murders take place in the space of hours and Dr Blake finds himself investigating both, the only clue linking them is a pouch of tobacco.
Dr Blake becomes involved in the grisly murder of a cinema projectionist and Jean becomes involved with Richard Taylor. How will Blake feel about a beau for Jean?
When a second body is found in a coffin, Doctor Blake has to work out how it got there and who killed this unwanted guest and that's just the start of it.
When a Ballarat school Principal is found dead, Blake and Lawson find themselves back at the school where they first met as boys.
Art student and life model, Vanessa Mackay, is brutally killed and her keys are used to steal a painting from the Ballarat Art Gallery. But what is the real motive?
When the old parish priest is found dead, Doctor Blake needs to unravel the secrets and lies of parishioners in order to get to the truth.