Mindy Lahiri can quote every romantic comedy starring Meg Ryan that exists. She loves the good ones and the bad ones, because the girl always gets the guy. Mindy is determined to be more punctual, spend less money, lose weight and read more books – all in pursuit of becoming a well-rounded perfect woman…who can meet and date the perfect guy. Mindy is a skilled OB/GYN and shares a practice with a few other doctors, none of whom make life any easier for her. Jeremy Reed is the walking definition of total bad news. He not only shares a practice with Mindy, but sometimes her bed as well – despite her best efforts to resist. He is funny, self-absorbed and super sexy. In contrast, Danny Castellano is a hothead and guys’ guy who has a habit of stealing Mindy’s patients. As Mindy attempts to get her career off the ground and meet a guy who passes her red flag test, only time will tell if she gets her romantic comedy ending.
After getting drunk and disorderly at her ex-boyfriend's wedding, Dr. Mindy Lahiri realizes she needs to get her personal and professional life back on track.
When Mindy is tasked with hiring a new nurse, she has to consider Morgan (Ike Barinholtz), a reformed ex-convict while Jeremy tests his breakup skills when he fires a problematic, elderly nurse.
When Shauna takes the office to the hottest nightclub in town, Mindy meets an unlikely potential suitor named Josh, who works as a lawyer for the New York Knicks. Meanwhile, Jeremy attempts to hit on a bride-to-be, and Morgan unexpectedly makes some extra cash as the club's bathroom attendant.
When Josh invites Mindy to a Halloween party, Mindy stresses out about finding the perfect costume to impress him. Meanwhile, Danny and Jeremy leave work early to finally take their driver's license tests, much to Danny's embarrassment.
When Mindy must find a new gynecologist, she asks Danny to assume the role. Eventually, he accepts - on the grounds that Mindy will feel too uncomfortable to go through with the exam. The two then play a game of chicken to see who will back out of the deal first. Meanwhile, Jeremy tricks Morgan and Betsy into helping him break into Mindy's apartment to retrieve a valuable item.
Mindy decides to cook Thanksgiving dinner at Gwen's house, but she is completely caught off guard when her former blind date, Dennis, arrives with his new girlfriend. Meanwhile, a lonely Danny mans the empty office while Betsy and Jeremy visit Betsy's eccentric family for the holiday.
Mindy is confronted with an awkward situation when her teenage neighbor comes to her for birth control. Meanwhile, Danny receives an anonymous complaint that Morgan has been inappropriately ogling Shauna.
Mindy isn't getting respect from Danny and Jeremy, so she goes off to experience life as her own boss. Meanwhile, the group fights back when they discover that holistic midwives are stealing patients from Shulman & Associates.
When Mindy throws an office Christmas party at her apartment, she is eager for her colleagues to finally meet her boyfriend, Josh, but her plans go awry when she discovers a secret that Josh has been hiding. Meanwhile, Jeremy deals with doling out the office holiday bonuses, much to everyone's chagrin.
When Mindy's brother visits from college, he tells Mindy that he wants to drop out and start a rap career, immediately causing Mindy to panic. Meanwhile, Danny and Jeremy lift the spirits of their elderly landlord with the hopes that she will reduce their office rent.
Mindy's goddaughter, Riley, demands that Mindy get a bunk bed for their sleepover. But Mindy's plan veers off-track when Morgan and Danny help to build the bed, and it collapses, injuring Gwen in the process. Meanwhile, Shauna and Betsy find some surprising items when they snoop through the office in an attempt to find out who's stealing the People magazines.
Mindy wants a one-night stand with Brendan, the midwife who once stole her patients, but things go wrong when Brendan's brother, Duncan, and Morgan show up. Meanwhile, Eye Patch and Danny go out on a date.
Mindy thinks she finally meets the perfect guy, Jaime, only to find that he's way too close to his female best friend, Lucy. Then, when Danny gets dumped by Jillian, he tries his best to get her back with the help of Morgan.
Mindy tries to solve Jaime's best friend problem by pairing up Lucy with Danny on a Valentine's Day double date. However, Danny and Lucy hit it off immediately and sparks fly, ruining Mindy and Jaime's date. Meanwhile, on his way to his hot Valentine's hook-up, Jeremy helps Morgan with his pickup skills.
When Mindy is asked to host a medical segment on the local news, she turns to Maria Menounos for help; Beverly has a difficult time keeping up with modern culture and technology when she returns to work as an administrative assistant.
Mindy reunites with her "first kiss," Sam. The two reminisce about their time at Jewish summer camp, and soon rekindle the sparks of their teen romance.
Mindy's friends and co-workers unintentionally throw her the worst birthday party ever. And, after storming out, Mindy stumbles upon a new group of friends with whom to celebrate. But when she ends up in a fight with her new pals, she receives help from someone in her recent past. Meanwhile, Danny and Jeremy compete for the affection of Mindy's friend.
Danny gets caught sneaking out the office supply of painkillers for his troublemaker childhood friend Stevie who has instant chemistry with Mindy. Meanwhile, Mindy is in for a shock when Heather, Josh's ex-girlfriend who ruined Mindy's Christmas party, shows up at her doorstep to ask for her blessing to move into her apartment building. Mindy says yes, but immediately begins to plot ways to ruin Heather's rental application.
When Mindy goes on a date with a cute minister named Casey, she feels compelled to attend his church to show him that she is a good person. But when Casey admits to Mindy that he thinks she's a selfish person, she decides to go on the practice's volunteer trip to a women's prison to prove him wrong.
When Mindy decides to have a night out by herself in the city, she hits it off with a stunningly handsome man who turns out to be a prostitute. Horrified, Mindy tries to avoid him until she realizes she needs a date for Danny and Alex’s dinner party, so she gives him a makeover a la “Pretty Woman”
As the doctors of Schulman and Associates prepare for a medical conference in Santa Fe, NM, Mindy receives a message from her ex-boyfriend, Josh, who is now living there and wants to talk. But Mindy is in for a surprise when she discovers why Josh moved west. Meanwhile, Morgan helps Jeremy work on a potentially career-changing presentation, which doesn’t go according to plan.
When Danny's ex-wife, Christina, comes back to New York to confront Danny about an emotional letter he had written to her, Morgan confesses that he had sent the letter unbeknownst to Danny, causing Danny to fire Morgan out of anger. Meanwhile, the rest of the staff compete in a triathlon and go head-to-head with the midwives, who have hired Morgan to work for them.
Mindy acts as a mentor to a college student. But when Casey and Mindy unexpectedly hit a rough patch, she decides to drown her sorrows at a frat party where she reunites with her old flame, Tom, and all hell breaks loose. Meanwhile, Danny and Jeremy try to woo Morgan away from the midwives.