The Suite Life of Zack and Cody stars identical twin brothers Dylan and Cole Sprouse, as Zack and Cody, whose lives change when their mother Carey (Kim Rhodes), ends up landing a job at one of Boston’s finest hotels, the Tipton Hotel. As part of Carey’s contractual deal, the twins and her get to live in an upper floor suite of the hotel. Ashley Michelle Tisdale stars as Maddie Fitzpatrick, who plays the role of the hotel candy counter girl and part-time babysitter, that tends to having to put an end to Zack and Cody's antics. Brenda Song stars as the rich and spoiled hotel heiress, London Tipton; while Phill Lewis plays the role of Mr. Moseby, the Tipton Hotel Manager.
Maddie helps London become smart to win over the affection of a scholar. Meanwhile, Cody moves into the coat closet and makes it is own room after he has enough of Zack's sloppiness.
Zack and Cody fall for a French girl who can't speak English very well. Meanwhile, somebody steals London's purse and Esteban tries to help.
Maddie runs a Daycare Service at the Tipton, and when Maddie has a family obligation to attend to, Zack and Cody take over. Meanwhile, London encourages Mr. Moseby to take yoga to help him relax a bit more.
A food critic is coming to the Tipton Hotel. Cody ends up having to fulfill the duties of being head chef, after the Tipton's regular chef suddenly quits, on a very important day.
The boys end up trying to save a horse, which is no easy task trying to keep it hidden. Maddie loans something that is very sentimental to her to London and is mad at her when London loses it.
Zack and Cody have to repair a wall that they damaged as punishment. London begins attending Maddie's private Catholic school due to her poor grades.
Cody runs for class president; Zack decides to run as well, but for the wrong reason. Mr. Moseby gets annoyed with one of the staff members.
Mr. Moseby gets worried when his older brother Spencer arrives at the Tipton for a visit. Zack and Cody buy a bike, but they have to share it. Maddie and Esteban mess with London's horoscope.
Cody is disappointed when he finds out that Zack is doing better than him in woodshop at school. London takes credit for a book that Maddie wrote.
Maddie is having her Sweet 16, and likes to have her party at the Tipton. On that same day, London decides to throw her own bash. Zack ends up trying to figure out what to get Maddie for her special day.
A twins convention is being held at the Tipton Hotel. Zack ends up creating a double date with twin sisters, for him and Cody. London and Maddie end up enjoying a evening with twin brothers.
Zack borrows money from a guest named Maynard to play video games, but starts to fear him when he can't pay it back. Cody enters a spelling bee. London and Maddie help a homeless family.
Mr. Moseby and the Tipton Staff is challenged to a bowling competition, by its rival, Ilsa and her team. Zack is the star bowler for the Tipton, but ends up having to be replaced due to getting grounded. Zack's replacement must overcome his emotional scars, due to a past bowling incident.
Zack makes a new rich friend, who is mean to Cody and thinks he is a dork. Maddie and London have to do a parenting project for school as partners.
Zack and Cody discover a machine of Arwin's creation that can transport people from one dimension to another. They hop in, and find themselves back at a mixed-up version of the Tipton Hotel; where London is a candy girl/babysitter, Maddie is an air-headed rich hotel heiress, and other personalities are switched.
Arwin could win a trophy and a kiss from Carey, if he ends up winning an annual competition for "Hotel Engineers"; in which the boys help Arwin train and compete. Maddie ends up getting hired by London to work at her new boutique.
Zack dreams that he has gone back in time to the Boston Tea Party with his family and friends, where an act of protest by Maddie inspires the him to launch a present-day battle to save a historical park in Boston that's being threatened to be demolished.
A hotel guest trips on Zack's skateboard in the lobby. But when the boys find out that's he's lying in order to get free service, they come up with a plan in order to set things straight.
Cody gets Zack a job at the school newspaper for the advice column since the previous person quits. When a girl he likes asks for advice, Zack tells her secretly to ask him out. So she does. But when she finds out about him giving the advice, Zack is in for a load of trouble. London can't sleep and Maddie, Mr. Moseby & Esteban try to help her sleep.
Raven Baxter is stuck in Boston, where she has a vision that something bad will happen to Cody. After warning him, vaguely, he becomes paranoid. Meanwhile, Maddie tries to get London into wearing Raven's dress, but London is too stuck up to do so, until pop star Hannah Montana arrives at the Tipton, and wants to wear the dress herself.
One of Cody's favorite bands is playing a concert at the mall. Cody is tempted to skip school with Zack and Bob, so he can see the band perform. Meanwhile, London meets her new young step-mother.
Zack and Cody's school is putting on the Shakespearean play, "A Midsummer Nights Dream", where Cody tries to keep a certain kiss involving his new girlfriend and Zack from happening, and Zack tries to get a girl. London uses the principles of feng shui as she redecorates the Tipton.
It's International Day at Zack and Cody's school and Zack decides to ask a guest named Kumiko, a Japanese opera singer, to be his project. After Zack loses Kumiko, Carey and the boys must fill in as Japanese singers for a convention being held at the Tipton. Meanwhile, Maddie and London get trapped in London's closet.
Cody, is having difficulty dealing with the fact that Carey has a new boyfriend. But, Zack and Kurt do not have a problem with him because he is rich. London joins Maddie's volleyball team and ends up being rather good- but only when she is mad.
Mr. Moseby schedules a ballroom dancing competition at the Tipton to help raise money for Esteban's sisters 'Sweet 15' party.
Zack convinces Cody, Jessica, and Janice to go see a scary movie, but when it's Zack who gets scared, Cody uses it to his advantage. Meanwhile, London likes a boy so she pretends to be poor for him to like her.
Zack and Cody join the Wilderness Scouts with their leader being Mr. Moseby. Cody becomes jealous when Zack turns out to be a better outdoorsman. Meanwhile, London claims that Maddie stole her former boyfriend and both plead Carey for advise on her "relaxing" day.
When a hawk comes and lays her egg Arwin scares it away and somebody has to take care of it. Cody agrees, and he does a good job at parenting. Maddie tries to protest about getting rid of the bird.
Zack has to take on the responsibility of taking care of Carey and Cody due to them being ill. Cody uses his illness to his advantage by making Zack his servant. Meanwhile, Mr. Moseby makes an announcement about the "Employee of the Month" and it's employees compete for that title.
Zack and Cody convince Mr. Moseby to open a club for kids in the hotel's lounge in which they would manage. London has her own line of cosmetics in which she needs help coming up with a name for it.
The twins compete on a game show in which Cody does the mental challenges, while Zack has to do the physical challenges. Maddie mistakenly sends Mr. Moseby an angry e-mail which she tries to retrieve.
Zack receives help for a history report from Mr. Moseby's grandmother, when she comes to visit. Meanwhile, Mr. Tipton forces London to get a job.
Zack and Cody go on a double date to a miniature golf course. Zack tries to impress his date, Ella, but things backfire on him. Cody and his date, Barbara Brownstein, have an intellectual attraction. London joins a bookclub with her rich friends much to Maddie's amazement. Carey tries to become a more healthy-living person.
When the Tipton holds Health and Fitness week, everyone begins to examine their eating habits. Cody helps Chef Paolo in an attempt to lower his cholesterol, while Carey begins to limit Zack’s sugar intake. Meanwhile, London and Maddie participate in a charity fashion show where they are both criticized about their looks, each taking drastic measures to change.
When a wheelchair basketball team visits the Tipton; Zack and Cody's basketball team plays an exhibition game against them. Meanwhile, Maddie is filming a movie for a student filming contest. She hires Lance, London and Mr. Moseby, but they're all terrible, so she has to figure out a way to make her movie a success.
When Zack and Cody get discovered by talent scouts the Tipton staff goes to Hollywood to go watch a pilot of Zack and Cody's lives being filmed.
Becoming Hollywood stars starts to go to the boys heads.
When Zack and Cody knock an ancient mummy over the balcony, Zack dresses Cody up to replace it for the exhibit. Esteban is scared of the curse of the mummy, so he and Maddie try to swap the mummy for Maddie's old doll.