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In the first episode of the new series Davina meets Sarah-Jayne Croft a 47-year-old teacher from Hampshire who has battled with her weight throughout her adult life. After reaching almost 25 stone, Sarah decided it was time to take action and is pledging to lose 10 stone to fit into a sexy superhero costume, which she bought a few sizes too small to give her an incentive. After seeing a fellow passenger on a plane making comments via text about her weight, Sarah-Jayne decided it was time to finally take control but will she succeed?
In the second episode of the new series, Davina meets Robin Dixon from Clacton-on-Sea who is hoping to lose 10 stone to help get his old self-back. The 37-year-old has battled with his weight his whole life and tipped the scales at 36 stone. Now with serious health issues, Robin has decided it's time to take action. Will he be able to lose the weight and get his life back?
In the third episode of the new series, Davina meets father of three Chris Peters, who has set himself the challenge to lose 7 stone. The plumber from West Sussex has decided its time to get fit for the sake of his family, but will he be able to achieve his goal?
Lewis Burns, 16 from Glasgow is hoping that this is the year he will finally be able to speak again. After diagnosed with the heart condition ‘sudden death syndrome' Lewis tragically suffered a heart attack aged just 10, as a result he suffered damaged to his windpipe. With his windpipe almost completely closed, Lewis hasn't spoken for six years but has now decided it time to undergo surgery that will reopen his windpipe and allow him to talk again. Will Lewis finally gain his voice back?
Carol Ubaldi, a 54-year-old from Cardiff is hoping she can finally put an end to years of yo yo dieting. The catering manager is hoping she can lose 7 stone, but will she be able to finally achieve her target weight?
Conrad Andrews from Halifax has had a fear of the dentist since his teens after suffering a traumatic experience. The repercussions have meant that the 33-year student hasn't visited a dentist in 20 years and is now constantly embarrassed by his teeth. Will Conrad be able to face his fears and finally get a smile he is proud of?
Kathryn Mallery, 34 and Chris Chapman 37 from London are hoping to complete their family with the help of a surrogate. Diagnosed aged 7 with a rare disease that means she is at constant risks of tumours, Kathryn, whilst pregnant with her first child, developed a tumour causing her to go blind in one eye. Told that she could potentially lose her sight completely if she fell pregnant again, Kathryn and Chris are hoping a surrogate will help them finally be able to complete their family.
A woman hopes to lose half her body weight and a man who harbours dreams of competing in the Paralympics.
In this episode Davina meets childhood sweethearts Fiona and David Eastwood both 38 from London who are hoping they will finally be able to have their longed for child via a surrogate. The pair have been together for nearly 25 years and have suffered years of failed IVF attempts. Will this be the year they finally get their wish?
Russel Newland, 54 from Surrey is renown in his local area for his ‘pirate' image and whilst he relishes his notoriety, his is less happy with his weight. The Relief Shop manager is hoping to lose 7 stone and smarten up his look. Will Russel finally be able to achieve his goal?
Kelly James 37 from Bradford is hoping to finally find love. Working unsociable hours as a local police officer, Kelly has decided that now is the time to stop putting her love life on hold but will she finally meet her Mr Right?
Gemma Trotter, 33 from Surrey is hoping that she will finally be able to walk unaided. The fitness instructor tragically lost her leg aged 14, after being involved in car accident. In 2013 the pin to which her prosthetic was attached snapped and had to be removed which means Gemma has to rely on crutches. With a young son, Gemma is hoping to undergo surgery and rehab to allow her to walk unaided once again.
Fay Chambers 43 from Leicester is hoping to lose 10 stone and finally gain the confidence to get on a plane for the first time. The Paediatric Health Care Assistant has battled with her weight since childhood but with her honeymoon to Mexico looming Fay wants to overcome her fears and finally board a plane.
In the final episode of the series, Davina meets Rebecca, 37 and Richard Francis, 35 from Camarthen in Wales who are hoping to finally be able to extend their family and have a child. After suffering a number of miscarriages and unsure if this is linked to Rebecca's diabetes, the couple are hoping a new treatment method will allow them to finally have the baby they long for.
Injured veteran Luke Reeson is hoping to make the GB Paralympic swim team and head to Rio. The 27-year-old from Cumbria took up swimming after suffering a gunshot wound to his leg and groin whilst serving in Afghanistan and found a new career path. Will Luke be able to achieve his dream and earn a place on Team GB?
Bus driver Adrian Brown, 39 from Hertfordshire is hoping to find love by the time he turn's 40. Working unsociable hours has made dating difficult but with his birthday fast approaching, Adrian is hoping that this will be the year he finally meets his Miss Right!
Long time friends, Andy Hill, Ian MacKenzie and Jim Allison are each hoping to lose 6 stone. Fed up with their weight, the truck drivers from Scotland have decided to go head to head in a healthy competition to see who can be the biggest loser!
Rryann Ashworth, 20 from Manchester is hoping to have a full body lift so she can finally show off her impressive weight loss. The student nurse lost a staggering 10 stone via a gastric band operation but is now hoping to have a full body lift to remove the unsightly excess skin and achieve the body she has longed for.
Sam Redington 47 from East London is hoping that he will finally be able to walk again. The dad of three was living a happy and healthy life when he tragically contracted a rare syndrome where the body's immune system attacks the nervous system leaving him paralysed and wheel-chair bound. Through intense rehabilitation, Sam is hoping that within 12 months he will be able to walk once more.
