When Melanie's mother comes for a surprise visit, Trapper learns that Melanie has kept their divorce a secret from her for the last six years. Gonzo suggests that a doctor should work as a nurse for a week to get a better idea of the problems they are having, and he gets volunteered for the job.
Trapper falls for a hospital scrubwoman Slocum falls for a patient.
Jackpot recommends surgery for a man who suffers from Munchhausen's disease, a psychological disorder which leads him to fake symptoms.
A miserly industrialist with an obsession for anonymity badgers the hospital staff.
A bitter former hospital employee takes Riverside hostage and demands $1 million ransom.
On a foggy Thanksgiving, Slocum hits Trapper with his car. As John fights for his life, staff members recall (in flashbacks) reasons they have to be thankful for his friendship and help.
Doctor Albright dies from a heart attack. Gonzo and Shoop send Trapper on vacation to Geneva Springs. While Trapper substitutes for a small-town doctor, Riverside is fired and a former patient of Trapper's needs heart surgery.
Talented neurosurgeon Russ Brandis enduring a deadly disease and fits of rage he shows are due to the drugs he must take. The surgeon's personal problems are uncovered as Riverside and Gonzo try to recruit him for the hospital staff.
A Soviet diplomat is admitted with pain from a liver tumor.
Vinnie Duncan, Gonzo's good friend, leads a fund campaign for rare-disease drugs.
A baby admitted to the hospital for a urinary tract infection turns out to be a hermaphrodite, sparking a battle between the parents over which sex it should be.
When Gloria Brancusi learns that Andrea, the orphan girl, has come back to the hospital as a patient her first reaction is to run away. Gloria has second thoughts after deciding to adopt the troubled orphan.
An emotionally troubled musician is released much too early from the hospital. Nurse Shoop suffers a hearing loss.
A brilliant surgeon begins suffering from bouts of forgetful and disoriented behavior.
Gonzo's professional confidence and bedside manner are affected by a malpractice lawsuit, after a young patient asserts he has begun to feel worse from an emergency operation made him. A patient is mistaken for a hospital inspector.
A woman from Riverside's past is obsessed with him.
Trapper fears an epidemic after the leader of a research project becomes mysteriously ill.
Gonzo's mother introduces him to her new boyfriend, a sportswriter his age. Gonzo is not happy about the situation.
Gonzo starts dating a high society woman who tries to convince him to leave the hospital and set up a private practice. She also talks him into selling the Titanic to Jackpot.
Gonzo runs out of gas in front of a decrepit apartment building where a woman has been injured on the broken stairs. When he traces ownership to SFM and brings it to the board, they agree to do something - tear down the building and put up condos.