Betty finds that everything is changing as she begins her new job as associate features editor, especially since her boss is her ex-boyfriend, Matt Hartley, who is still unhappy about their breakup. In addition, Betty's new officemate, Megan, openly resents her, while Marc is constantly undermining her because he felt he was more deserving of the promotion. Meanwhile, without Betty as his assistant, Daniel is adrift, still mourning the loss of his wife, Molly. Betty tries to help Megan out on an assignment and connects with a thoughtful insect jewelry designer, Olivia, while Justin starts high school and is victimized by bullies-but won't tell his mom, Hilda. Claire Meade is finding that her power struggle at the company has her sitting pretty - for the moment -- opposite Wilhemina, who lost her claim to the Meade throne last season. But Wili has perhaps an even bigger problem than job security - she is harboring a secret at home that is driving Marc to distraction.
Betty gets to run her own Mode photo shoot at the United Nations to promote their anti-malaria initiative, "Nothing but Nets," but her big opportunity becomes a baptism by fire when Daniel's neediness takes its toll, and Matt openly demoralizes her. Meanwhile, Amanda does some soul-searching when she bonds with Daniel's new temp, Helen, a career receptionist as fabulous as Amanda is. Wili makes it her personal mission to protect a loved one, and Hilda reaches out to Marc to figure out how to help Justin.
Betty tries to get a scoop with Gucci's new designer, Evan York, through Hilda's customer, Sammy. Marc tries to stop her by getting Amanda and Matt to stage a showdown at Ignacio's restaurant. Daniel goes to a bereavement group and meets Natalie who shows him an interesting night. Wilhelmina flies to Bermuda to try and find Connor.
Betty has Marc as be her temporary assistant thanks to Wilhelmina. Betty ends up covering the worst jobs in New York as an assignment but she needs to dress up as a hot dog and perform a Bollywood style dance. Marc has insecurities about how his idol at Vogue magazine will perceive him. Daniel is targeted by the leader of the Community.
At Wilhelmina's fund-raiser for Tibetan orphans Matt asks someone to be his partner. Daniel hires Natalie as his assistant, making Betty feel unneeded. Daniel finds out that Claire has a secret.
Hilda has doubts over her relationship with Archie after seeing an old flame Bobby Talercio. Marc helps Justin to fit in high school by telling him to become friends with some mean girls. Elsewhere Daniel is lured into a trap by Bennett. Wilhemina tries to come up with money to help Nico out of trouble.
Daniel hands over the power to the Community of the Phoenix to run Mode. Betty steps in to help Daniel with Bennet. She comes up with an cunning plan with the help of Claire. Wilhemina goes out in public wearing sweats creating mayhem with the media trying to get a scoop.
Betty, Matt and Amanda's love triangle in the Bahamas reaches boiling point. Betty has trouble with a photo shoot when Penelope Graybridge steals the shoot from her enemy Wilhemina. Marc falls for super sexy Troy.
Ignacio prepares a romantic dinner for his Jean. Betty and Hilda take the Be-Shure instant pregnancy tests. Meanwhile, Hartley gets Denise Ludwig to fill in for Wilhemina. However Marc plans to bring Willie back. Claire with Amanda track down Tyler, the son she gave up for adoption.
When Betty becomes concerned that she and Matt are spending too much time together, she tries to give him something else to be passionate about -- a surprise gallery showing of his art work -- with unintended results. Meanwhile, Marc is horrified that his one-night stand, Troy, is falling for him, since Marc was Troy's "first", Hilda grapples with whether or not to tell Bobby that he's the father of her unborn child, and Cal officially replaces Wilhelmina with Denise. Jesse Tyler Ferguson returns as Betty's orthodontist, Dr. Farkas, for a cameo, and Christine Ebersole guest stars as Frances, the gallery owner.
A battered but unbowed Betty recounts her worst week EVER to Mr. Z (guest star Fisher Stevens) as the show flashes back to her horrible last few days. Frustrated over the frivolous assignments Wilhelmina gives her at Mode, and inspired by Audrey Hepburn's memoir, Betty creates her own blog about amazing charitable ventures that inspire her. However, as her hobby enriches her, her job is nearly killing her, since Wilhelmina tortures Betty with beauty experiments for future stories. Meanwhile, Daniel fears Marc is sabotaging him -- and he is; Bobby treats a hormonal Hilda to some pampering during "Hilda Week," which goes awry, and Wilhelmina makes a long-term commitment to the incarcerated Connor.
Betty tries to be neighborly by planning a karaoke party in her apartment building, but before the big day, her building is robbed, and it's partly her fault. Marc is distraught since he lost something irreplaceable in the theft. Meanwhile, Daniel and Wilhelmina are back to being at each other's throats, so Amanda tricks them into attending couples counseling with Dr. Sparks (Frank Whaley), and Ignacio refuses to accept Bobby in Hilda's life. Then a citywide blackout ups the ante for everyone.
Wilhemina is livid when she lays eyes on drag queen impersonator - Wilhediva Hater. Betty and Daniel go through a rough patch as she wins an award for her blog. Daniel has the press hot on his heels. While Marc is pleased with himself when a famous director does a photo shoot with him.
Daniel helps Betty to cover a low-priority show. Betty discovers a new designer, Marisa, and decides to promote her however she faces stiff competition from Marc. Amanda struggles to persuade Marc or Betty to vouch for her to Wilhemina about her clothing line. Tyler tries to find Claire in New York.
To speed along the investigation into her house fire, Betty is pressured to date an annoying fireman. Wilhemina tries to prove to Don, an old flame from her past, that she's just "Wanda from the block" instead of an uber-bitch, and Amanda draws closer to Tyler, convincing Claire to hire him as an in-house model at Mode. Meanwhile, Hilda meets Bobby's parents for the first time.
Justin loves his acting class, helmed by the eccentric Lena Korvinka, and finds himself in an unexpected triangle with his new pals, Austin and Lily. When Betty drops by class, she's smitten with a cool young playwright, Zachary, whom she will profile for Mode. But she challenges her own ethics when she starts dating him. And Wilhemina is hospitalized with a perforated ulcer, and can’t help her type-A personality even when bedridden, but then her roommate, Roberta, prompts an epiphany.
Betty is thrilled to get her braces off, courtesy of her chatty new orthodontist, Dr. Frankel. But before this can happen, she gets knocked unconscious at a photo shoot of the "Million Dollar Bra" at the Guggenheim, spinning her into a dream sequence. An angelic Dr. Frankel shows her how different her life would have been had she never worn braces. She's the "pretty sister," while Hilda is homely, Ignacio is a compulsive gambler, Marc is a doting dad and Amanda is married to Daniel. But glam Betty is also mean - she's in cahoots with Wilhemina to terrify and overpower everyone at Mode.
Betty gets an assignment to cover London Fashion Week, accompanied by Amanda, and she brings Hilda along as a bachelorette party treat. She reconnects w/Christina and also runs into Gio (Freddy Rodriguez) unexpectedly. Willie joins AA to get closer to Tyler and to double-cross Claire and Daniel, and Bobby can't figure out why Justin is spending all his time with Austin -- until he can.
As Hilda’s wedding day approaches, Betty asks Daniel to be her plus-one, Ignacio invites Elena, and Amanda is set on fixing up Marc with her new client, soap opera star Spencer Cannon (Bryan Batt). Meanwhile, Justin weighs whether his own plus-one could be Austin, Betty considers unexpected offers in her personal and professional life, and Wilhelmina finds a way to fight the Meade empire by using Tyler as her pawn.
In the series finale, Betty's reluctance to tell Daniel about her future is holding her back, Justin and Bobby go in search of a new place - although Hilda doesn't seem too keen. Amanda struggles to deal with the death of her dog, Halston, and Marc thinks he is destined to be alone.