Uncle stars stand-up comedian and singer/songwriter Nick Helm as Andy, a dissolute out-of work musician who forges an unlikely alliance with his 12-year-old nephew Errol after being morally blackmailed into looking after him by his chaotic sister Sam – all on the day Andy was planning to kill himself.
Andy's living in the basement of Sam and Bruce's new home, depressed over how things ended with Melodie and having cut off contact with Teresa after finding out she was pregnant. Now he has nightmares about the child he's never met, and it's playing on his conscience. Errol, meanwhile, is having Daddy issues of his own, unable to accept Bruce as the man of the house. This is causing Sam a headache, on top of the fact that Bruce is subtly hinting to her that he wants a baby. When Andy's offered the chance to write for a boyband, he has to decide whether financial security is more important to him than artistic integrity, especially when he has a kid in the wings. With Errol's help, Andy goes on a journey of self-discovery to find out whether he can man up and be a dad.
Things get competitive when Errol and Andy fall for the same girl. Meanwhile, Sam and Bruce feel the pressure of trying to conceive.
Andy stumbles into a drug-fueled whirlwind romance with singer, Jasmine, and suddenly finds himself engaged. Errol let’s a girl think he’s “experienced” in an attempt to look cool, and Sam has to find a way of telling the family some life-changing news. Unfortunately, Bruce’s mother and brother are coming to visit and everyone’s struggling with whether to clear the air or hold on to their secrets. It isn’t long before the lies spin out of control and Andy has to face up to some hard truths for the first time in his life.
Andy struggles to shut off his feelings. Errol struggles to let his in. Sam's life hangs in the balance. An impressionistic exploration of grief.
Andy and Sam's chaotic parents, Neville and Jane, visit from Spain and announce they are getting a divorce. While Sam obsesses on the fact her mother still doesn't pay her attention, Andy schemes ways to keep his parents together in an attempt to prove he can make any relationship work. And Errol decides to play Ben and Bruce off each other to buy him a trip to Europe. Who will win the manipulation game?
When Melodie shows up at Andy's flat they finally hash it out and confess their feelings for each other, but things don't turn out as he'd hoped. Meanwhile, in his fantasy writing class Errol spins a fantastical tale of Andy, now cast as a stable boy on a noble quest to find his long lost princess. With the help of Errol in the guise of a young stable master, the boys will encounter a slew of odd but familiar faces in this fantasy retelling of Uncle, possibly helping the real Andy get to the bottom of how he can win Melodie back.
Andy's creative juices are flowing and he's gathering a measure of success as a music producer. For the first time, he has to think about real decisions regarding what matters most to him - can he prioritise his career without hurting his relationship with his family? And what about settling down and having his own family? Can he be happy as a successful writer/producer, even if it means he'll never be a 'star'? Can he be a successful star if it might preclude a wife and kids? Errol is dealing with disillusionment and stability changes in his two new home lives. He's always put a priority on education and school, but now it's losing its lustre. He's looking for more from life, he's looking for meaning and being the smartest guy in the room's not doing it for him anymore, especially as hormones start to kick in.