Weird Science is a show based on the 1985 John Hughes movie of the same name. High school geeks Wyatt Donnelly and Gary Wallace create their dream girl, a magical genie named Lisa, on Wyatt's computer. Having a genie leads up to five seasons of unique adventures for the guys. The theme song for the series is the same as the movie- "Weird Science" by 80s group Oingo Boingo.
After Chett's girlfriend Rose breaks up with him after their date, he decides to take his anger out on Wyatt, which isn't unusual. To get Chett to leave him alone, Wyatt asks Lisa to create the perfect girlfriend for Chett. Using a fishing pole and a photo of Chett, they go ""fishing"" for Chett's perfect mate. They reel in Ali, a hot girl that finds Chett irresistible. However, it turns out that Ali is really an ugly alien from outer space. She does still want to get it on with Chett. Unfortunately for him, she wants to eat him for a snack afterwards.
After Chett almost deletes all of Lisa's files Wyatt's computer, the guys decide that they need to maximize security. Lisa creates a top of the line system to protect the computer from intruders. Of course, after about minute, Gary forgets the password that he chose. Now Lisa is locked out of her home and can't gain access to her magic, making her a normal human being. She has many new experiences, such as her first dream, her first time using the restroom, and her first crush. She also finds out what it feels like to have a broken heart.
Wyatt visits his Grandma in a nursing home and is saddened that she isn't the same old Nana that she used to be. He asks Lisa to give Nana the spirit of a young person, which Lisa does. Nana becomes more spirited, but the new energy is coming from other people- she's sucking the youth out of everyone that she meets. Gary and Wyatt turn into old teens and have to find Nana and return her to the nursing home before they die of old age.
When Chett almost gets struck by a bolt of lightning, Lisa makes Chett invincible to save him. Now, nothing can harm Chett, not even the fact that he was electocuted, run-over, and shot. Gary and Wyatt get Chett to use his powers for good, so Chett becomes the super hero, the Star-Spangled Butt Kicker. Chett works at helping to put a stop to crime. However, trouble occurs when his powers wear off while he's trying to stop some homicidal maniacs.
Gary decides to borrow Wayne Donnelly's lucky suit for his dad to wear. Just in case the suit isn't really lucky, Gary asks Lisa to zap the suit and make sure that it's really lucky. As soon as Al Wallace wears the suit, he finds a lot of luck at work. However, this new streak of good luck for Al is causing Wayne to have a huge streak of bad luck. Meanwhile, Chett finds a girl that likes him- a clinically depressed girl.
Gary decides to join the school newspaper as a reporter, in order to get closer the girl that serves as editor on the paper. The only problem is that Gary has never read any news except for tabloids. Gary has nothing to report about, so Lisa creates an equalizer, which is a magical pen that will make whatever you write come true. Now the town is full of UFOs, Elvis encounters, a two-headed Scotsman, and even Chett as a Yeti.
Wyatt finally gets with a date with Mindy, but needs a car to drive on their date. When his dad agrees to buy him a car, Wyatt excitedly imagines what kind of great sports car he'll get. Unfortunately for Wyatt, his dad decides to get him a junker, in order to try and not make the same mistakes with Wyatt that he did with Chett. So, Lisa zaps Wyatt's ""new"" car into Nadine. Not only does Nadine look great on the outside, she also has a wonderful personality. Wyatt falls deeply in love with Nadine and ends up breaking up with Mindy. When Gary and Mindy try to figure out what's going on with Wyatt, they become romantic themselves. That is, until Gary falls head over heels for the car, too.
After watching a movie entitled Bikini Camp Slasher, Lisa thinks it would be lots of fun if they all were zapped into the movie to experience it for themselves. After they enter the movie, they are chased around by Mittface, a murderer with a sickle. The only thing that they have to protect them is all of the rules that Gary knows about teen horror movies. Not only can they get killed by Mittface, but they are also in danger of getting taped over.
Phoebe, an old friend of Wyatt's, comes back to town. Both the boys think she's pretty hot and end up spilling the secret about Lisa to her. She then takes control of Lisa herself and has Lisa erase Wyatt and Gary's minds of the fact that they ever had a genie. Phoebe also becomes the host of her own daytime talk show, very similar to ""Sally."" The only thing that can help the boys remember is the fact that Wyatt keeps a daily diary-- I mean journal. The boys also get to be guest stars on an episode of ""Phoebe"" entitled Men Who Became Women Who Became Men Again.
A butt crack comment and a welt lead to the end of the Wyatt and Gary's friendship. To try and bring them closer together, Lisa zaps them into their favorite television show ever, ""The Sci-Fi Zone,"" which brought them together in the first place. While being narrated by Chett doing a great Rod Serling impression, Wyatt and Gary meet talking candy bars and dolls, a pig-faced woman, an evil fortune telling machine, and a satanic Principal Scampi. The boys have to either help each other or get stuck living in the Sci-Fi Zone where time has no meaning.
Lisa shows Gary what's going to happen in the future, only to reveal that Wyatt will end up stealing Gary's date to the prom. Wyatt tries to change the outcome of the future by having Lisa give him the worst personality that she can create. She zaps up a pair of magical Chett underwear, giving Wyatt Chett's personality. Unfortunately, Gary's date likes the new Wyatt even more and Chett is happy because his brother is finally becoming cool.
Lisa turns Gary and Wyatt into lifeguards ""Baywatch""-style. Everything's fine until Gary gets turned into a merman when he tries to save an environmentlist from drowning. Also, it turns out that there may be more than one magical genie in the world, when Lisa meets Kahuna, a mysterious man.
In order to let Wyatt try some different careers for later in life, Lisa zaps up some magical chocolates. One of the chocolates makes Wyatt a police detective who must clear Gary of stealing an expensive comic book. Meanwhile, Gary tries out some new careers, including talking to Chett on his 976-GARY, or otherwise known as the 976 CONNEXXION phone line.
Lisa zaps Gary up a pair of flying shoes. When Gary is spotted as a UFO, two FBI agents, agent Scolder and agent Molly, arrive to investigate the spottings. They find a real case with Lisa, a magical genie.
Wyatt and Gary think that being a genie would be easy. Lisa thinks that being a teenager and going to high school is easy. So, they switch places. The now teenage Lisa falls head over heels for the popular guy at school, Lyle, and tries to make friends with girls who aren't very accepting of her. Meanwhile, the guys try their luck at zapping up things, messing up every time.gets turned into a poodle
When Lisa performs a seance, it of course doesn't go right. Chett brings, Uncle Baldash, a member of the Donnelly family back to life. Uncle Baldash was a warrior during the 1100s. Chett loves his new uncle and goes back in time in order to live as a warrior. This means that Wyatt has to go back in time to save Chett from getting killed.
Gary is dumbstruck when he finds out that his relatives weren't all cowards and losers. He has an ancestor named Red Brick Wallace, a gunslinger from the old west. Lisa zaps them back to the old west in order to meet Red Brick Wallace. Unfortunately, he turns out to be nothing more than a spittoon polisher. The guys are now on a mission to save Red Brick Wallace from getting shot by the sheriff, who looks strangely like Chett.
Lisa creates a virtual reality game in which Gary and Wyatt can pretend that they are spies. After Gary breakers the machine, the game takes on a life of it's own and becomes real. Farber High becomes very interesting as the boys are trying to stop Scampfinger, the evil Principal Scampi, who wants to put all of the world's water inside of a dixie cup. Wyatt also gets a full cavity search from Chett.