Weird Science is a show based on the 1985 John Hughes movie of the same name. High school geeks Wyatt Donnelly and Gary Wallace create their dream girl, a magical genie named Lisa, on Wyatt's computer. Having a genie leads up to five seasons of unique adventures for the guys. The theme song for the series is the same as the movie- "Weird Science" by 80s group Oingo Boingo.
Gary wants credit for bringing Lisa to life, so Lisa gives the guys the opportunity to meet someone who can understand, Dr. Frankenstein. However, Dr. Frankenstein isn't too appreciative. He doesn't want two teenage boys to have done a better job at creating life. Lisa is extremely intelligent, while Dr. Frankenstein's monster is dumber that the village idiot. What's the doctor to do? He decides to take all of Lisa's energy and use it as the basis for his ""Bride of Frankenstein."" Gary and Wyatt, trapped with Dr. Frankenstein, must figure out how to bring Lisa back to life.
Lisa's spell goes awry when she zaps Wyatt and Chett into The Yankee Dudes, a powerful wrestling team. They become a top pair of wrestlers in the pro-wrestling world and must face the German wrestler, Der Blitzkrieger.
Gary's having fun meeting girls online. He's made an especially good friend named Cori. Wyatt and Lisa thinks that Gary needs to actually meet her in person, so they pose as Gary and ask her out on a real life date. Gary can't believe that they did this and he can't go out on the date. He's told Cori that he looks like a magazine model and even sent her a scanned photo of a model to go along. Lisa solves his problem by creating a handsome puppet Gary that looks exactly like a magazine model. Gary can control the puppet while it goes on the date with Cori. Gary has fun until he finds out that Cori really likes the puppet, in fact she likes him more than the real Gary.
The alien race known as Steve kidnapps Chett and replaces him with an Chett look-alike android. The alien race known as Steve wants Lisa for their queen and has Android Chett kidnap her. Lisa objects to being queen because that would mean that her job would be to procreate and keep the dog-face alien race known as Steve populated. Wyatt and Gary now need to rescue Lisa and Chett. Unfortunately, the alien race known as Steve have their own weapon- Isaac the Bartender from ""The Love Boat.""
In order to get Principal Scampi off of his back for a while, Wyatt shoots him with a buddy dart. The dart makes Principal Scampi Wyatt's new best friend. When Wyatt gets sick of hanging around with the principal, he decides it's time to break up the relationship. Principal Scampi then becomes Phantom Scampi. Phantom Scampi lives in Farber High and secretly protects Wyatt.
There's a hacker in town. This hacker has made changes to Lisa's files, replacing her face with a picture of Abe Vigoda. Now that Lisa no longer has her body, people aren't as nice to her and pretty much just ignore her. Lisa solves the problem by making everyone in the world think that old men are the sexiest things on the planet. Now all the kids at Farber High are bringing old men to the Homecoming dance instead of hot dates. Wyatt's on a mission to find the computer hacker and get Lisa looking like her usual self.
While at a carnival, Gary and Wyatt see a hot girl, Valerie, and have a falling out when they fight over her. Lisa zaps the boys into the carnival funhouse and leaves them there until they can stop fighting. They have fun opening mysterious doors trying to find Valerie, and Wyatt seems to get all the good ones- he even gets a puppy out of it. In the end, the guys both get dissed by Valerie as she chooses an evil funhouse clown over the both of them.
Lisa gets trapped inside of Principal Scampi's computer. In order to get Lisa back, Wyatt and Gary need to steal the computer. They enlist the help of Chett and create a plan to break in and get the computer.
Gary screws up yet again. This time he has sucked all of the intellignce from everyone at Farber High, using a magic brain vacuum. The brain power from the students forms into a giant orb that wants to take over the world. Gary must outwit the wit of every single student at Farber High.
Mr. Donnelly gives Chett the boot and kicks him out of the house until he can find a job. Unfortunately for Chett, there's nothing that he's qualified to do. Wyatt asks Lisa to zap up ""A Man's Man's World"" and creates a monster truck-cigar-jerky-paintball store, since those are the only thing that Chett's any good at. Chett gets a job at the store, working for Mickey and Rhett, who strangely resemble rats. In fact, they are rats. Lisa accidentally turned Rhett and Mickey, two alley rats, into humans. The bad news is that the rats plan to wipe out the human race by using the plot from Invasion of the Body Snatchers. Chett, not really realizing what's going on, aids them in their quest.
After Gary and Wyatt wish that they could time travel, the wish goes bad and they end up stuck in 1969 along with Lisa. After six months of being in the past, they realize that Lisa can't remember anything. She thinks that she's a hippie on her way to Woodstock. Wyatt and Gary need to get across the country and fix Lisa's memory or be stuck in the hippie age. Wyatt, Gary, and Chett all go on a road trip across the country, even meeting the future president.
Wyatt and Gary are making a film entitled ""Night of the Blood-Sucking Zombie Sophomores."" Lisa even zaps up a couple of real rotting zombies to act in the movie. Everything is running smoothly until the zombies decide it's time for lunch and want to eat Principal Scampi's brain.
On Halloween Lisa gets possessed by Cyber-Demon, an evil creature from the bad side of the internet. Now Cyber-Demon has complete control of Lisa and her powers. Not to mention the fact that the evil demon is sucking everyone's brain juice to feed itself. Now the only person that can help Gary and Wyatt is the mysterious ""Repairman.""
In a box of Chett's old junk, Wyatt finds his old favorite toy, the Cyborg Sam action figure. Apparently, Chett had stolen it many years before. Lisa tries to help Wyatt have fun with his toys again, so she brings Cyborg Sam to life. Wyatt finds that having a man dressed up in a space suit follow him all day doesn't help out his lack of popularity.
After Chett hits Wyatt in the face with a ceramic ashtray, Wyatt wishes that Chett could see what his life would be like without Wyatt around. Lisa, always eager to help, zaps up a world where Wyatt has never been born, but only exist as phantoms. The plan doesn't work out as planned when Wyatt finds out that everyone ends up having a better life without him around. Gary's now the big man on campus and Chett's heading off to college. Even worse, Lisa can't bring herself and Wyatt back from the alternate planet. Their only option is to somehow get Gary and Chett to create a genie of their own.
It's time for Lisa's second birthday, but she isn't very happy because she doesn't have any family members or any other friends to invite to her party. Wyatt and Gary decide to give her the ultimate birthday gift by creating fake memories of a family life for her. Her party goes well until her family shows up. It turns out the Lisa's magic brought her family to life without her knowing. Her family consists of a secret agent dad, a barbarian queen for a mom, and her private detective brother, a chimp named Chad. Another unexpected guest shows up as well- Lisa's old boyfriend, Ripsaw the Gladiator. Lisa is set on marrying Ripsaw and Gary and Wyatt can't change her mind. The only way to stop Lisa from getting married is by Gary beating Ripsaw in a fierce game of miniature golf.
When Gary makes a wish under his breath to try eyeliner, Lisa overhears, but mistakenly hears that he wishes he could fly a jet liner. So Lisa zaps the boys into a plane, but when neither of them know how to land it, she saves the day. However, Lisa is not allowed to be seen by everyone, so Gary and Wyatt get all of the credit for the landing. The President would also like to throw a ball in their honor and present them with an award. Since the ball is high profile, they leave Lisa at home and head off. Lisa is hurt by the fact that the guys won't even allow her to attend, but she decides to go to the ball anyway. She meets the President and they fall in love. Unfortunately, the President doesn't seem to have enough time in his schedule for Lisa. So it's up to the boys to talk to the President one on one and fix Lisa's broken heart.
Gary starts dating Jenny Dreeson. Unfortunately, there's always a problem. Jenny's whole family hates Gary. Gary makes a wish that the Dreeson family loved him. The wish doesn't turn out as planned when all the members of the Dreeson family decide that they now want to date Gary. Gary's happy to oblige, and doesn't even realize the fact that dating an entire family isn't the best idea ever. Meanwhile, Chett gets to meet his future self, Robo-Chett.
Gary, Wyatt, and Lisa all decide to go clubbing after hours and become ""creatures of the night."" Lisa turns them all into cool vampires, except the fact that they crave Yoo-Hoo instead of blood. Being vampires gives the guys new powers. They now have the ability to hypnotize people, which they enjoy using on cute women. The night turns out to be not so great when they find themselves with a real group of bloodsucking vampires. Principal Scampi and Chett are determined to stop the vampires and become vampire hunters.
Wyatt is sick of his parents not paying any attention to him, so he wishes that his family could be closer and have better family values. Lisa's plan backfires and creates an world in which Wyatt has a family with very strong ties to each other- a family similar to that of the ""Godfather."" In this world, Wyatt Donnellis and his family are the masters of the Homeowners Association. They fix neighborhood Little League games and take kickbacks from children's lemonade stands. However, trouble is in store when Al Wallace tries to take on the Donnellis family. Gary and Wyatt find themselves against each other in the war.
Lisa gives the school a technological upgrade to fufill Wyatt's wish. Unfortunately, Gary and Wyatt end up in a bad sci-fi movie plot from the 80's. In this school, zombie teenagers are having their hormones taken away by Future Scampi. Gary and Wyatt are considered outlaws and are hunted down by the team of hall monitors that Scampi has assembled.
Gary and Wyatt are fighting over the use of Lisa. Lisa gets annoyed by the fighting over her and decides to let the boys battle it out in court. Genie Cyber-Court, that is. The winner of the case wins the genie. Gary and Wyatt choose their own lawyers. Gary choosing B.F. Jackie (similar to Cockran), while Wyatt chooses Abe Lincoln. Both lawyers argue out each of their client's side. However, neither Gary nor Wyatt are found to be suitable to be awarded custody of Lisa, so she will be broken down the Internet will be given custody of her.
After receiving too many memory-wipes from Lisa, Chett develops a brain callous that no longer allows his memory to be erased. This allows Chett to know about Lisa and the fact that she's a magical genie. Of course Chett wants to do harm instead of good. He immediately tries to lie, bully, and buy his way into getting his very own genie from the guys. Unfortunately, instead of a genie, he gets a nice ride to the insane asylum.
Wyatt gets the lead role in ""Jolly Roger,"" the school musical. Wyatt has a crush on his leading lady, Jessica, unfortunately she doesn't return his feelings. Lisa tries to make her feel differently, but magic goes awry, and the musical is brought to reality. Now the entire high school is filled with singing pirates and their prisoner, Principal Scampi. Not to mention the fact that they choose a new King, Chett. Not too long after the pirates are discovered, they break out of school in their ship and go about town singing and dancing.
Chett swallows a very rare invitation (complete with directions) to an underground rave. So, Lisa miniaturizes herself, Gary, Wyatt, and a space ship. They take a ride inside of Chett in hopes of getting the directions back. Just as in ""Fantastic Voyage,"" Lisa, Wyatt, and Gary get to see way too much of Chett... The complete inside of him. However, during the trip, Chett's girlfriend Sharon breaks up with him, and Wyatt gets Post Miniaturization Stress-Syndrome, causing him to go mad. Wyatt tries to ruin the plans of the mission, and the ship ends up running out of oxygen. Lisa and Gary need stone cold Chett to cry, or else be trapped inside his body with no air.
Lisa grants Chett a wish- to be stranded on a deserted island. However, as usual, Lisa's magic goes awry, and Lisa is trapped on the island with him. Not only are they on a desert island, but they are in the middle of the Bermuda Triangle, which hinders Lisa's magical powers from working. Not only do Chett and Lisa not get along, but a hurricane is headed directly for the island. Gary and Wyatt try to rescue the two, but have trouble when facing their nemesis- Adam West.