Set in 1989, the series follows 9-year-old Sheldon Cooper as he attends high school in the fictional town of Medford, Texas, and tries to fit in the world around him while his family and friends attempt to deal with his unique intellectual capabilities and social challenges.
After Sheldon dismantles the refrigerator to stop an annoying hum, he gets a paper route to pay for the repairs.
When Dr. Sturgis bonds with Paige, another 10-year-old genius, Sheldon’s jealousy leads Meemaw to intervene. Mary invites Paige’s family over for a play date.
When Mary’s faith is shaken by a tragedy in the community, Sheldon becomes an unlikely ally.
When George Sr. asks Sheldon to keep a secret from Mary, the stress of not being honest drives Sheldon to hideout at Tam’s for his first sleepover.
Dr. Sturgis recommends Sheldon and Missy for a university research study on twins, and Mary is unhappy when the test results go to Sheldon’s head.
Mary clashes with Sheldon’s drama teacher over plans for a Halloween fundraiser for the church. Also, Georgie falls for a rebellious teenage girl that Sheldon is tutoring.
Sheldon gets into trouble with fellow child genius Paige at the science museum. Also, George Sr. is forced to play therapist to Paige’s bickering parents, and Mary, Georgie and Missy help Meemaw with a garage sale.
A video game takes over Sheldon and Meemaw’s life. Also, George Sr. is jealous when Georgie bonds with Herschel at the auto shop.
Sheldon studies his family for a psychology project, and Thanksgiving dinner turns into a family fight when George Sr. is offered a job in Oklahoma.
When Sheldon learns that people with stunted childhoods can turn into social outcasts, he tries to act like a kid. Also, Meemaw and Dr. Sturgis' relationship is tested when she teaches him how to drive.
Sheldon experiments on Missy while Georgie joins Mary’s Bible study to spend more time with his crush, Veronica.
When Sheldon spends a few days at the hospital, he turns out to be the worlds worst paitient. Missy gets a taste of what it would be life like if she didn't have a twin
Sheldon attempts to build a nuclear reactor. Also, a university cocktail party gets heated when Dr. Sturgis' colleague, Dr. Linkletter, flirts with Meemaw, and Georgie is heartbroken when he learns Veronica has a boyfriend.
Sheldon uses his new friendship with the school bully to boss Georgie around. Also, Missy steals Meemaw's makeup for picture day.
Sheldon and Dr. Sturgis have their first fight when Dr. Sturgis marks a question wrong on Sheldon's test. Also, Mary takes over for Pastor Jeff when he's out sick.
Things spiral out of control when Sheldon boycotts his favorite bread company. Also, Georgie offers Veronica a shoulder to cry on when she's dumped by her boyfriend.
Inspired by his hero, Albert Einstein, Sheldon tries his hand at the violin. Also, Mary and Meemaw secretly buy a pregnancy test when Mary thinks she's pregnant.
Sheldon moves in with Dr. Sturgis for the weekend to see what his life will be like in college. Also, a lonely Mary tries to bond with the other Coopers during Sheldon’s absence.
Unhappy that school funds are going towards football rather than academics, Sheldon decides to run for class president.
Georgie is thrilled when Veronica stays at the Coopers’ house for a few days. Also, Meemaw and Dr. Sturgis celebrate their one-year anniversary.
The Coopers help Pastor Jeff through a rough patch in his marriage. Also, Sheldon pressures church members for donations when Mary takes him to work for a day.
Sheldon invites the entire school to a party for the Nobel Prize announcements. Also, Meemaw learns more about Dr. Sturgis' past, and Georgie's desire for cable TV leads to a standoff between him and George Sr.