1x01 The Good Son

This is a perfect pilot.

Niles: "You know what I think about pop psychiatry."
Frasier: "Yes, I know what you think about everything. When was the last time you had an unexpressed thought?"
Niles: "I'm having one now."

Daphne: "Nice to meet you. [sees Eddie] Oh, and who might this be?"
Frasier: "[darkly] That is Eddie."
Martin: "I call him 'Eddie Spaghetti.'"
Daphne: "Oh, he likes pasta?"
Martin: "No, he has worms."

Niles: "I thought you liked my Maris!"
Frasier: "I do. I... I like her from a distance. You know, the way you like the sun. Maris is like the sun. Except without the warmth."

Frasier moves to Seattle, but he was slightly funnier in cheers.

Trivias
Jane Leeves's good friend, Valerie Bertinelli, was in the studio audience and her laughter can be heard throughout the episode.
Goofs
When discussing the possibility of a live-in health care worker, Martin suggests the room across from his, Frasier's study, for her to stay. In later episodes, Martin's room is shown to be on the same side of the flat as Frasiers, whereas Daphne's is on the opposite side past the kitchen.

Perfect start to the best series ever! It shows the heart and humor that continues for 11 more seasons. Love it.