Ten years ago, the Mars probe brought back the Pandora Box, which emitted a light that caused the ground to raise, and a massive wall to appear. Society has called this the "Skywall Tragedy". Japan has been separated into three sections, with three capital cities known respectively as Hokuto, Seito, and Touto. They were all in conflict with one another. It is now present day. In Touto, mysterious unidentified lifeforms called the Smash appear. Sento Kiryu secretly transforms into Kamen Rider Build, and he's sent day after day to fight against the Smash. However, Sento has no memories of the last 20 years. He only remembers, "A scientist in a gas mask, human test subjects, and a bat man". What on earth does all of this mean? Sento is employed at the Touto Institute of Advanced Matter Physics. While continuing to fight as Build, he will also be responsible for unraveling the mystery of the Pandora Box as a researcher. It's at this time that Ryuga Banjo makes a jailbreak in the middle of serving a prison sentence for murder. The Smash detected Ryuga and reacted to him. Sento tries to catch Ryuga, but Ryuga tells him an unexpected fact to try to prove his innocence.
Because Build saved a jail breaking murderer whom he believes is innocent from the Touto government, he is now labeled as a wanted fugitive. At home, Sento listens to Ryuga's situation, which may lead to solving the mystery of his memories. While visiting a scientist, Takumi Katsuragi, who Ryuga was supposed to have killed, the police surrounded the room at the moment when Ryuga discovers Takumi's body. There's a possibility that he was framed. It was supposed to be Ryuga who was unable to reveal anything else, but he suddenly escapes from the base, forcing Sento to go after him...
Sento and his friends follow the clues regarding Nabeshima, the man responsible for framing Ryuga. When Ryuga contacts Nabeshima, he agrees to protect Nabeshima's family, unaware that a trap is waiting for him.
After getting another of his memories back, Sento investigates the connection between Faust's experiments and the Pandora Box. Meanwhile, Ryuga tracks down Nabeshima's family and stands up to protect them from the enemy.
While confronting Souichi about his connection with Faust, Sento is informed by Sawa about a hint regarding a person who may know his true identity.
Ryuga interferes with Sento's attempt to rescue his friend Tatsuya, intending to use Tatsuya to track down Faust's base. Now Sento not only is forced to fight Tatsuya again to save him, but must confront Ryuga as well.
Now suspicious that he may be the responsible for the murder of the scientist Katsuragi, Sento's doubts about his true character increase, unaware that the enemy is closer than he thinks.
Sento discovers that Katsuragi was the founder of Faust, and approaches his mother to learn more about Katsuragi's intentions, and obtain more clues regarding his lost memories.
Sento and Ryuga discover that Katsuragi was involved in creating a Build Driver of his own, and his possible involvement with Sento widens the distrust between them.
Upon learning of Faust's plan to steal the Pandora Box, Sento and Ryuga set out to Touto Institute of Advanced Matter Physics to protect it.
Faust stole the Pandora Box and almost all of Sento's Fullbottles. One of his few remaining ones, the Dragon Fullbottle, is proven too strong for his current powers, until he comes with an idea.
After learning from Sawa about the connection between Faust and Nanba Heavy Industries, Sento and Ryūga confront them to retrieve the Pandora Box and their stolen Full Bottles.
After learning the truth from Nabeshima once he had regained his memories, Sento confronts Blood Stalk to retrieve the Pandora Box.
Sento discovers that Sōichi, the man who sheltered him is actually Blood Stalk, leading to a decisive battle between them.
Sento retrieved the Pandora Box from Sōichi, but the revelation that Night Rogue is Gentoku Himuro makes him realize that now the entire Touto government is his enemy.
Upon Gentoku's revelation that he and Takumi are the same person, Sento falls into guilt, and a furious Ryūga challenges him to a battle, just when a third, mysterious Kamen Rider appears.
As Touto is invaded by Hokuto, Gentoku asks for Sento and Ryūga's help, and the Riders must decide what to do next.
Sento confronts Kazumi Sawatari, an assassin from Hokuto, wondering how the enemy got his hands on his latest invention.
With he and Ryūga unable to beat Kazumi and his men with their current strength, Sento searches the files left by Takumi to look for an alternative.
Sōichi approaches Sento and gives him an item that can stop Ryūga's rampage, but using it involves a huge risk.
Despite knowing the risks, Sento uses the Hazard Trigger to empower himself against Kazumi's three subordinates. After losing his consciousness and killing one of them, Sento is struck with guilt and refuses to keep fighting, until Soichi gives him an alternative.
Sento and Kazumi have a duel to settle the war, but when the enemy proves himself too strong for him, Sento has no option but to use the Hazard Trigger again.
Taking advantage of the conflict, Seito invades and conquers Hokuto. Now bent on seizing all of Japan, the Seito forces invade Touto, led by the mysterious Kamen Rider Rogue.
Gentoku reappears as Kamen Rider Rogue, determined to get revenge on Touto. To stop him, the other Kamen Riders decide to join forces, when Sento perceives something strange happening with Misora.
Just as Gentoku is about to finish off Sento and the others, Misora appears before them, and the secret behind her mysterious powers is revealed.
Seito challenges Touto for another proxy battle to end the war once and for all. Sento and his friends make preparations to confront Gentoku and his subordinates, unaware that one among them is a traitor.
The proxy battle to end the war is tied with one victory to each side, and for the decisive bout against Gentoku, Sento unleashes a new power.
Despite using his new powers, Sento is having a hard time against Gentoku, and Sawa reveals to the others the reasons for her betrayal.
The war between the nations has ended, but Sōichi and Namba finally reveal their true intentions as a new conflict begins when they open the Pandora Box.
Vernage, the Queen of Mars possesses the body of Misora to assist the Riders in retrieving the Pandora Box, revealing an important secret about Ryūga in the occasion.
As the Riders invade the Pandora Tower to retrieve the Pandora Box, a new power bursts from Ryūga, just as questions about his true identity are raised.
Doubtful about his own origins, and eager to know the reason why he was framed in the first place, Ryūga confronts Blood Stalk demanding for answers.
Touto's Prime Minister, Taizan Himuro was kidnapped by Rogue! Why? The answer is revealed through Sōichi who is possessed by Evolt: "Prepare the Evol Driver in exchange for Taizan Himuro's life." But just what is the Evol Driver? Sento was confused as well until he finds plans for the design of this ultimate Driver contained within the research data belonging to his father, Shinobu Katsuragi.
Kamen Rider Evol was born, and the first victim of his power was Taizan Himuro, the prime minister of Touto! Evolto now engages a full-scale onslaught to complete the Pandora Box, and his next target is Sento. Evolto infects Sento with an alien poison that can only be cured by Evolto. Because of this, Sento’s life is on a deadline as he demands the remaining Fullbottles and the Pandora Box in exchange for Sento’s life. Just what will the remaining Riders do now?!
Evolto is close to attain all FullBottles and the Pandora Box, and with Ryūga under the enemy's control, Sento turns to Gentoku for help.
Having finally opened the Pandora Box, Evolto is about to destroy the entire world, until Vernage makes a move.
Evolto avoided his destruction by possessing Sento's body. Unable to transform, Ryūga looks for a way to save his friend.
Evolto reaches his full potential and seems unstoppable, while Sento recovers his memories as Katsuragi.
To face the full power of Evolto and Utsumi, Sento combines the power of all Fullbottles to unleash his most powerful form.
Surprised with the advent of Build's new form, Evolto decides to begin the last steps of his master plan.
Sento discover that his father is alive, and by searching the files he got from his mother, he learns why the Rabbit and Tank Fullbottles have a special meaning to him.
With Sento confused with the fact that his father might be in cahoots with Evolto, another person transformed into Kamen Rider Build appears before him.
As Sento still tries to figure out his father's true motives, Misora is kidnapped by Evolto and transformed into a Smash.
Kazumi and Gentoku infiltrate Faust's headquarters in Hokuto, but Utsumi appears to face them. Meanwhile, Sento confronts his father, who reveals the true reason why he joined forces with Evolto.
With Evolto defeated, Shinobu reveals his true objective to the Riders.
Suddenly Evolto, who was impersonating Seito's Prime Minister Mido, reveals himself to the world and his intentions to destroy it! This marks the beginning of the final battle of Evolto vs. humanity. All of the Kamen Riders including Sento are determined to fight until the end. Their key to victory lies in the White Pandora Panel originating from the data that Shinobu left behind. Evolto's planetary destruction has begun. The fight for the last Lost Fullbottle is on the line. The Kamen Riders set their aim at the summit of the Pandora Tower, and Evolto himself!
Despite Sento's warnings, Kazumi uses the Blizzard Knuckle to attain a new, powerful form, knowing that he will not survive the transformation.
With no time to mourn for Kazumi's death, Sento, Ryūga and Gentoku brace themselves for the final battle against a full-powered Evolto
After the sacrifice of his companions, it's up to Sento to protect the world by defeating Evolto once and for all.