Ewan McGregor and Charley Boorman set off on a 15,000 mile trip from John O'Groats to Cape Town. After finding a suitable base, Ewan and Charley spend several months in London prior to departure, planning a route that will not only be challenging but will also be inspirational and visually arresting. Eve, Ewan's wife, decides she would like to join part of the trip. Ewan is over the moon but Charley's not so sure as she's never ridden a bike before. Meanwhile, as part of their training, the team attend a hostile environment course where they are faced with the kind of difficulties and dangers they may encounter in Africa. Then, two months before departure, Ewan has an accident and breaks his leg, jeopardising the future of the trip. But that's not the only problem - departure date looms but worryingly the team still dont have their visas for Libya. Six have been promised, but for the two Americans on board things are not looking promising, and tensions arise as a split between the crew looks unavoidable. With the visa situation still unresolved for the Americans, the team take their vehicles and make their way up to John OGroats to start this epic adventure and what will be a journey of a life time.