Finally after three years of courtship, Migs (Dingdong Dantes), a medical intern, marries simple and unassuming Joy (Marian Rivera), a nurse in the hospital of Migs' residency. Several days before the wedding, his first love and childhood best friend Bela, a sophisticated woman, (Iza Calzado) returns from Canada, still single and in love with Migs. The young couple meets an unfortunate incident turning their newly-found bliss into a tragic existence. Living with Migs turns out to be an agonizing experience as his new state of mind gets more complicated as days pass. A creature of serenity, Joy refuses to name her pains and secretly vows to make Migs remember their love that was inexplicably lost and waiting to be rekindled; faithful that along the way, his heart will remember what his mind forgets.