Martin Witz's THE SUBSTANCE: ALBERT HOFMANN'S LSD is an informative and entertaining investigation into the history of a drug so potent that mere fractions of a milligram can alter a subject's perception of reality. Viewers learn how Hofmann's discovery became the subject of 1950's Cold War experiments by the American military and the CIA, who saw LSD as a potential weapon. Meanwhile, international psychiatrists and consciousness researchers tried to unlock the drug's medicinal possibilities, wondering whether it might be an effective tool for contemporary psychiatry or neuroscience. In the early 1960s, Hofmann's "miracle drug" escaped from the lab.
