De Zwarte Weduwe is niet dood… Drugskoningin Carmen van Walraven zit ondergedoken in Canada en leidt daar een anoniem leven. Ze houdt zich overal buiten, totdat er op een avond een collega lastiggevallen wordt en Carmen niet anders kan dan haar te hulp schieten. Uit zelfverdediging vermoordt ze de dader, wordt opgepakt en uitgeleverd aan Nederland. Terwijl haar kinderen in shock zijn dat hun moeder nog leeft, zijn er ook wat mensen die nog een rekening met Carmen hebben openstaan. Iedereen wordt weer meegesleurd in een emotionele rollercoaster waarbij de problemen zich in rap tempo opstapelen. Carmen zal nu definitief moeten afrekenen met haar verleden om haar familie te redden.
Carmen realizes the business concerns of her husband Frans are not strictly legal when her son, Boris, finds a gun in his father's car. Frans admits he's lived in fear since a drug exchange went wrong.
Frans is in intensive care and Inspector Leeflang tells Carmen the police have been observing his hash-smuggling business. Steven, Frans' business partner, gets a visit from a rival gang looking for their missing drug haul.
Carmen's brother Irwan reveals that, along with Frans and Steven, he stole a drug haul from a ruthless dealer Christian Schiller. Believing she's now obliged to pay the debt, Carmen reluctantly agrees to run the family 'business'.
Carmen pays a visit to Christian Schiller who denies all knowledge of blackmail and instead asks for a favor: if she can re-open the transport route for a consignment of drugs, he will leave her family alone.
Carmen is forced to find a new contact at the harbor before the transport can go ahead. Andre is furious when he finds out about Schiller's stolen stash, but Irwan insists Frans was behind it all.
Carmen asks Schiller if they can postpone the transport, but he has debts of his own to pay and refuses, telling her that he taken something as insurance. Will Steven squeal to the police?
Carmen and her children agree to leave Amsterdam by faking a trip on Frans' boat while secretly planning a dash to the airport. Memories about his father's murderer come back to haunt Boris.
Boris is able to tell his mother about the identity of his father's murderer, but Carmen doesn't know who to believe and Steven's wife reveals the truth behind the drug haul.
While Irwan is preparing to wed his pregnant wife Hanneke in jail, his sister, Carmen, is settling into her new, anonymous life in a distant town in the Netherlands. But when a detective shows up pleading with her to testify against her brother, it seems that it won't be so easy for Carmen to leave her past behind her.
Carmen is visited by her father Andre's right hand man, Luther, who asks her to forgive her brother Irwan. Having narrowly escaped an attempt on her life, Carmen is now being forced to choose between justice and the wishes of her dying father.
Carmen continues to feel under threat and calls on Luther for help, but they soon become accomplices when yet another attempt is made on her life. Irwan meanwhile is preparing for his release from jail and is blackmailed by an old rival.
Luther and Carmen send a message to the people wanting her dead. Natalie leaves home for Amsterdam and Irwan spots an apportunity to offer Carmen an olive branch but he soon finds himself in grave danger once more.
Carmen goes on a dangerous pursuit to find Irwan while Hanneke goes into labor. Upon meeting her new nephew, Carmen is confronted with the state of her own family and her relationship with John de Weerdt.
When a dead body surfaces, tension and distrust mounts within the family. Hanneke reveals her own suspicions of Carmen to Detective Leeflang and soon the District Attorney encourages the investigation to focus on Carmen.
Carmen is arrested and put into isolation. She begins to worry when evidence emerges of her potential involvement in a brutal murder and the District Attorney uses news of Natalie's erratic behavior in Amsterdam as leverage against her.
At a family funeral, Carmen is confronted with the shady figures who dragged her back into this dangerous criminal underworld. She realizes that she must prepare a strong offence of her own in order to protect what's left of her family.
With Luther is detained for murder, Carmen decides to pursue Henk Ooms on her own. But when things begin to unravel as she executes her plan, will Carmen come out on top of this brutal game?
With blood on her hands, and Simon Zwart cutting a suspicious figure, it seems less likely than ever that Carmen will be able to escape the clutches of this dangerous underworld. But then she makes a discovery that changes her belief in everything she held to be true.
Carmen plans to launder a large sum of money through one of Simon Zwart's construction projects and leave the cocaine business behind. She tries to bring property tycoon Jack van Zon in on the deal.
Carmen prepares to do whatever it takes to save her latest consignment from a rival gang. Serbian criminal Zarko proves a ruthless opponent, and it seems the Justice Department haven't been so quiet.
Now her latest shipment of drugs has been intercepted by the Justice Department, Carmen's plans to get out of crime are in tatters, and Rosales holds her responsible for the entire missing consignment
Carmen is increasingly convinced there's a mole in her organisation. She suspects a number of people, including Storm. John is arrested by the police on suspicion of failing to stop after an accident.
The Mexican cartel send a delegation to the Netherlands to interrogate Carmen and Rosales. A police operation is set up, headed by Jim Leeflang, aiming to arrest them as soon as they make contact.
Carmen goes into hiding on an old canal boat that used to belong to Frans. Now that Luther is back on her side, she gets him to protect the children and find out for sure whether Storm is the mole.
Carmen comes up with a plan to get the seized drugs back from the Justice Department and return them to the Mexican cartel. Leeflang tries to get Natalie on his side, and John decides he's had enough.
Carmen organises a meeting to clear the air and draw a line under the past, but Berry isn't easily pacified and plots to steal the drugs. Property tycoon Jack van Zon visits Sandrina and Simon Zwart.
Social Services threaten to remove Carmen's parental authority. She asks Luther to take little Irwan to safety while she makes preparations to leave the country. Jack van Zon holds Sandrina hostage.
Carmen's plan to flee abroad with the children has come together, but the net is closing around her and Jim Leeflang is hot on her heels. She must risk everything to escape from the world of crime.
Business is going well and Carmen starts preparing her retirement. During Boris's birthday party there are problems in the harbour. Carmen has to decide what has more priority.
Carmen wants to know how were the kidnappers and decides to work together with xtc trader Marcus en his son Davy. After the kidnapping, Storm starts to see his work for Carmen in a different way.
Carmen is furious when a new container arrives without coke. She plays a dangerous game with the Mexicans, but it is the question whether they are responsible. Who wants to take over Carmen's role?
Now Carmen knows who's crossing her, nothing seems to be standing in the way of solving the problem. The lawyer is forced to call on help from the cartel to keep the minds calm.