Set after the events of Titans, the Doom Patrol – consisting of Robotman, Negative Man, Elasti-Woman, and Crazy Jane, and led by Dr. Niles Caulder / The Chief – receive a mission from Cyborg that they cannot ignore and will change their lives.
The team, tired of being stuck in Doom Manor, decides to visit the local town while The Chief is away. However, this seemingly harmless field trip leads to some grave consequences, including an encounter with the mysterious and powerful Mr. Nobody.
Following Mr. Nobody’s capture of Niles Caulder and the destruction of Cloverton, Ohio, The Doom Patrol investigate the mysterious albino donkey and discover it is a door to another universe, one where Mr. Nobody is in control. Cyborg aka Vic Stone, a part man/part machine hero from Detroit who has his own complicated relationship with Niles Caulder, joins the search.
The Doom Patrol set out for Paraguay where they discover the Nazi doctor who created Mr. Nobody and the connection between The Chief and the two villains.
Willoughby Kipling conscripts the Doom Patrol into helping him avert the end of the world by stopping a nihilistic cult.
With the Apocalypse in full swing, the Doom Patrol must work with an unlikely ally – and a very special pug – to stop the end of the world.
Jane, Larry and Rita visit a school where the original Doom Patrol has retired. Meanwhile, Cliff & Vic bond over their mutual “father issues.”
After a violent outburst from Cliff, the team engages in some self-led group therapy – leading to some growth within the group as they are knit closer together.
A sentient, gender-queer, teleporting street named Danny who’s being hunted by the secret Bureau of Normalcy needs help from Niles – but gets Vic and Larry instead.
Jane retreats into The Underground, a treacherous place deep within her own mindspace, where she encounters her many personas and dark traumas of her past.
Vic and Rita face a dangerous man called The Beard Hunter, who’s been activated by the Bureau of Normalcy to find Niles Caulder.
While Larry pays a visit to his long-lost love, Cliff and Rita travel to Gator Country to reconnect with his daughter. Vic worries about his operating system.
With Vic captured by the Bureau of Normalcy and held at the Ant Farm, his father, Silas Stone, hatches a plan to break him out with the rest of the Doom Patrol, but everything doesn't go according to plan.
The Doom Patrol tries to restore the memories and abilities of Flex Mentallo, while Rita confronts her self-doubt and Larry realizes how tied he is to the Negative Spirit.
The Doom Patrol finally lands on the threshold of rescuing the Chief from the clutches of Mr. Nobody. With help from Flex Mentallo and Danny the Street, the group enters the White Space, where Mr. Nobody offers a chance to start again.
In the wake of the Chief's revelation, the members of the Doom Patrol go their separate ways. When Mr. Nobody hatches a new plan, the team must reunite to help the Chief with a new, unexpected -- and weird -- threat to the world.