Four comedians and lifelong friends compete to embarrass each other out amongst the general public with a series of hilarious and outrageous dares. When Sal, Joe, Q, and Murr challenge each other to say or do something, they have to do it. And if they refuse, they lose. At the end of every episode, the biggest loser must endure a punishment of epic proportions.
Sal, Murr, Q and Joe climb to the Top of the Rock for some awkward interactions, then "wet" their appetites at a bagel shop; the evening's loser takes a run across the Brooklyn Bridge that is anything but inspiring.
Murr, Sal, Joe, and Q enlist shoppers to help them avoid a rogue security guard; the big loser faces the wrath of a crowd of rockers.
Q, Sal, Murr and Joe compete in a focus group face-off, convincing people that their TV show ideas are the best; the losers stand to get run out of town when they reveal their financial mismanagement plan to charity donors.
Sal, Q, Murr and Joe return to the dentist's office, then try to make each other laugh in a food court tournament. Tonight's big loser strips for a rowdy group of ladies who will never be able to un-see the sorry state of his skin.
Sal, Murr, Joe and Q don absurd disguises to trick unsuspecting receptionists, then try to convince strangers to sign off on some unusual emails; the big loser turns a harmless dance class into a dance with danger.
Murr, Joe, Q and Sal take a spin in a motorized chair hoping the kindness of strangers will keep them on track. Tonight's big loser walks away bruised and battered when he's forced to clear some tables in an unusual way.
Joe, Sal, Q and Murr skirt the law while posing as receptionists. The heat is on tonight's big loser as they try to give one unlucky customer the deal of a lifetime.
Murr, Joe and Sal pitch toys that should be kept away from tots, face off at a market, and see spots at the mall; the big loser sticks his nose where it does not belong.
Joe, Murr, Q and Sal run a surprise challenge; a stint at the Cake Boss's counter is anything but sweet; advice for children turns awkward when heard by strangers; the night's loser looks for a new do, but not for himself.
Joe, Q, Sal and Murr crack each other up while performing strange scenes behind glass, then test out awkward proposals at the Top of the Rock. And, tonight's big loser gets tongue tied while speaking before government officials.
Q, Murr, Joe and Sal have customers seeing red while working at an optician's office, then get too close for comfort eavesdropping on strangers' conversations. And, tonight's big loser gives the business at a networking event.
Sal, Joe, Murr and Q try and hold it together as receptionists checking in some strange characters. Later, they offer up odd rewards to helpful strangers, and tonight's big loser gets the stuffing squished out of him at the mall.
Q, Murr, Joe and Sal offer up peculiar specials at a steakhouse, and tonight's big loser may need his own lifeguard after making waves at the pool
Murr, Joe, Sal and Q have fast fingers at a focus group and leave no cereal box unturned at a grocery store. Tonight's big loser opens a can of something fierce at a local donation center.
Q, Joe, Sal and Murr rat each other out at a pizza place and get into textual relationships with strangers at the mall. Then, the big loser twerks hard for the money at an impromptu bikini car wash.
The Jokers perform unusual methods of DNA testing and get too close for comfort at the grocery store. Then, tonight's big loser becomes a shell of a man after he cracks under pressure during a presentation at a children's museum.
The Jokers act fast and furiously as employees at a theme park and go postal on model citizens who don't realize they're part of the picture. Then, tonight's big loser tumbles and falls after antagonizing a room full of Guy Fieri fans.
The guys turn on the charm to make a restaurant basement sound enticing and recruit unsuspecting shoppers to shout out bizarre nicknames. Then, tonight's big loser must find his way out of the cuckoo's nest before the chicks get crazy!
The guys pump the breaks on a bike ride to ask perplexed strangers for help and cut the java line to get the go-ahead on some very strange emails. Plus tonight's big loser gets schooled in a game show that barely makes the grade.
Q, Sal, Joe and Murr Greek out while lending a hand to customers at a casual restaurant, then battle across the table of a focus group. Plus tonight's big loser gets spitting mad when forced to spend some quality time at the zoo.
The guys try not to crack up during a four-way face off and later find that a stroll with the Gatto pups is no walk in the park. Plus, tonight's big loser suffers more than muscle failure in a major league embarrassment.
The guys rely on the kindness of strangers to help answer some awkward questions, then go looking for love in the park. Plus, tonight's big loser strikes out amongst baseball fans with an assist from Yankees legend Tino Martinez.
The Jokers pose as dental assistants where the laughing gas flows freely, and then make headlines for all the wrong reasons. Later, they get burned giving some campfire tips, and the big loser scores a hole in none on the links.
The guys try and work out the kinks as physical therapists, then pitch some way out-of-the-box ideas for TV hosts. Plus, the big loser gets rolled over by some speedy ladies.
The guys pair up to share educational ideas with perplexed parents, then teach Krav Maga to martial arts newbies. But when one Joker refuses, he becomes the big loser and faces an opponent that scares the pants off him.
The guys celebrate with some unseasonable specials, followed by unwanted new toys; gift wrapping goes awry; the big loser has a close encounter with hungry wildlife.