Gus (Paul Rust), an on-set tutor, is in a long-term relationship with Natalie (Milana Vayntrub). Gus angrily breaks up with Natalie when she reveals that she cheated on him and says he's not nice, just "fake nice". Mickey (Gillian Jacobs), a program manager at a satellite radio station, is in an on-again, off-again relationship with a cocaine addict, Eric (Kyle Kinane). Gus gets involved in a threesome and freaks out when he finds out that the girls are sisters. Mickey gets a call from Eric and decides to meet him at what she assumes will be a bar, only to find out that it is a spiritual meeting called Bliss House. The next morning, Gus meets Mickey at a store and offers to pay for her coffee because she's not carrying a wallet.
After Gus steps in to help Mickey out of an embarrassing situation, the two end up on a bizarre odyssey through the streets of LA.
Gus faces an ethically challenging situation at work, while Mickey navigates a dicey new dynamic with her boss.
Meltdowns and confusion ensues when Mickey invites Gus to a party and comes face-to-face with mistakes from her past.
As Mickey tries to get her life back together, Gus takes his date with Bertie to hilarious extremes.
A newly confident Gus gets noticed on the set, while a disturbing day at the radio station precedes an evening of Mickey behaving recklessly.
Gus sets out to dazzle Mickey on their first proper date, but the night doesn't go according to plan.
As Mickey frets over the fallout of her date with Gus, a new guest shakes things up at Gus's movie night jam session.
Gus gets an exciting opportunity at work, but a surprise visit from Mickey sends the day spiraling in a different direction.
Troubles keep mounting for Gus as he gets to experience life in the writers' room. Meanwhile, a new crisis pushes Mickey to a breaking point.