Newly hired teacher Satoshi Yabe begins his job teaching class 6-3 and soon becomes aware of the terrible Marui triplets, Mitsuba, Futaba and Hitoha. When the triplets notice Yabe might have a crush on the new school nurse, Aiko Kuriyama, they purposely try to injure his groin in the hope that Kuriyama will like what she sees. When Yabe incidentally gets injured after running into Kuriyama, she confuses him for a fourth grader (she's blind without her glasses). Yabe gets the class a pet hamster, which Hitoha names Nipples and becomes attached to. When others start to play with her too much, Hitoha starts becoming defensive.
Futaba catches a cold and ends up ensnaring Yabe into a rather long and sticky booger. Hitoha gets access to Yabe's apartment in order to see Nipples outside of school, blackmailing him from making other arrangements.
A boy named Yuudai Chiba catches a glimpse of Hitoha's erotic book and wants to see more of it, his friend Shinya Satou getting confused and assuming she wants to see her panties. Through certain events, Hitoha ends up meeting occult fanatic Sakiko Matsuoka, who mistakes her as being able to see ghosts. They end up sneaking into the pool before it opens, with Sakiko assuming Hitoha is trying to exorcise spirits, when she is actually drowning. During swimming the next day, the triplets forget their underwear and jump to the conclusion that they were stolen. When their suspicious looking father, Soujirou, arrives at school with the panties, Mitsuba is too embarrassed to admit losing them and implies he is the thief, getting him arrested.
During an art class, Futaba, who has an obsession with breasts, end up drawing various pictures of breasts, one of which the principal determines is a work of art. Whilst at the triplets' house, Shinya tries to stop Yuudai from playing around with Mitsuba's panties, only to get labeled as a pervert himself. This leads Futaba to believe Shinya has an interest in Mitsuba's panties, and continuously tries to give him large amounts of panties all day. When he tries to stop Futaba, Shinya ends up in another seemingly perverted situation in front of Mitsuba.
After being pressured by her classmates, Mitsuba goes with Futaba to buy a bra. Later, Nipples becomes attracted to the hamster design on Mitsuba's panties, making Hitoha jealous. Mitsuba gets into an argument with Miku Sugisaki over whose breasts are bigger, though ends up in an embarrassing situation. Soujirou is invited to the girls' parents day, though whilst trying to shave his beard to look less suspicious, he ends up shaving all his hair and looking even more suspicious. Mitsuba and Futaba get their essays about their respective feelings towards him mixed up, clashing with his expectations of them.
On the night before the Sports Meet, Futaba decides to rehearse for the event by having Soujirou fill in the other parts and obstacles. On the day of the Sports Meet, Futaba behaves ravenously in a game of piggyback, much to the lament of Hitoha and Mitsuba. Later in class, Yabe collapses with a fever, but when Hitoha goes to check on him, Sakiko is setting up some kind of ritual, which makes things awkward for Hitoha. During class, Miku tries to make Mitsuba jealous of her, but only ends up embarrassing herself.
Hitoha becomes fascinated by a sentai show called Gachi Rangers, though has trouble discussing it with others, leading to a confusing conversation between her and Yabe, who is also a fan of the show, when a wind picks up. A trio of Shinya's fangirls mistake a picture of Soujirou from the sixth grade that Futaba had been carrying with her as a picture of Shinya. One of the fangirls, Airi Ogata, competes with Futaba for the photo, but soon regrets it when her feelings end up with her sharing a bath with her and Soujirou. When Futaba tries showing her panties to Shinya (via life threatening kicks, no less) following intervention from Yuudai, rumor starts to spread around that Shinya would date girls who show them their panties, and they end up chasing him around school. Later, Futaba also becomes a fan of Gachi Rangers, which convinces Hitoha that she should apologise to Yabe for earlier. Classmate Yuki Yoshioka assumes that Hitoha is in love with Yabe and gets confused when conversation turns to obsession.
Following a game of Cops and Robbers, Mitsuba and Hitoha get locked in the gym equipment locker. Later, Hitoha becomes jealous when Nipples becomes accustomed to Futaba, which Yabe confuses to be something involving a boyfriend. Nipples however is found in Hitoha's pocket, preferring her company. Later, Hitoha and Futaba go to Yabe's apartment to handle a roach problem, with cockroaches getting all over Yabe's Gachi Rangers merchandise, causing misunderstandings between him and Hitoha. At the mall, Futaba comes across a lost child and plays around with him, despite the concerns of their respective family members, and the two end up getting lost on the outskirts of town. Futaba draws a picture of the child's mother to calm him down until police manage to find and return them.
When Yuudai tries to look at whatever Hitoha's reading, assuming it's a porn book, Hitoha, who was actually reading a Gachi Ranger guidebook, mistakes him for a Gachi Ranger fan, which somehow leads to him de-pantsing Yabe in front of her. Yabe tries to hold a talkshow corner with Mitsuba, but she's only interested in eating. On Christmas Eve, Soujirou, who usually plays the role of Santa for Futaba's sake, gets sick, so he has Hitoha take the role. When Futaba spots her that night, Hitoha has trouble escaping after pulling her hat over her eyes. On New Year's Day, Futaba fights with Mitsuba over a new pair of panties she got, and they end up blowing off into the wind. She ends up chasing them all the way to the shrine where they fall into the donation box. Later, Futaba wants a hot tub, so Mitsuba helps her take a tin drum home to use, only to find it lacking a base. Later, the school pool gets frozen over, and Mitsuba challenges Shinya and Yuudai to a game of ice bowling using Futaba as a ball. When Shinya has to kick Futaba, his striker skills send her flying.
During a joint recess with first graders, Mitsuba retrieves a RC coptor stuck in a tree belonging to Miku's little brother, Ryuuta, who is also a Gachi Rangers fan. When Hitoha shows him her merchandise, Mitsuba misunderstands the situation and comes off as a pervert. When Miku implies that Mitsuba is a 'nympho', Mitsuba gives her own definition when asked by Ryuuta, which comes back to haunt her when his classmates take it literally. Mitsuba and Futaba later find some of Hitoha's Gachi Ranger merchandise and inadvertently break them, ending up trying to steal replacements from Ryuuta. Whilst Futaba apologises to Hitoha, Mitsuba, who mistook her Gachi Ranger belt as an exercise belt, ends up getting punished after a failed attempt at pinning it on Soujirou. Later, Mitsuba gets a cold and becomes more irritating when Miku, Yuki and Miyashita come to visit. When Mitsuba's fever worsens, they and Hitoha have trouble getting a suppository medicine up to her. With Miku's help, they manage to get the medicine to her, only to later find it was intended for Sojirou's hemorrhoids.
Wanting to lose weight, Mitsuba uses Miku's cellphone as a substitute for an expensive exercise belt, later getting in trouble when Miku starts looking for it. Later, Mitsuba meets Miku's mother, Marina, who is, in fact, a masochist who asks Mitsuba to dominate her. Later, Yabe misunderstands a Gachi Ranger conversation between Hitoha and Ryuuta. Kuriyama mistakes Mitsuba for being injured and covers her in bandages, leading her to imagine that she's been kidnapped.
Misunderstanding Hitoha's fear of heights, Miyashita wonders if she hates her for being like everyone else in the class. Futaba becomes the next guest in Yabe's talk show. A simple game of dodgeball descends into chaos when Shinya's fangirls are involved. Wanting to get closer to Shinya, Airi offers to join him in a soccer match, but somehow ends up getting jealous of the ball. Later, Miyashita wants to become friends with Hitoha, so she learns about her fandom from Mitsuba. However, Miyashita inadvertently puts Hitoha in a tight situation where she is forced to reveal her Gachi Rangers belt to the class, becoming surprised to find that they're all fans, except for Miyashita.
Futaba goes into school with a fever, giving her a similar appearance to Hitoha and confusing Nipples, which shocks Hitoha. Hitoha ends up catching Futaba's fever, completing changing her aura. The girls convince Sojirou to let them keep a stray cat, only to find it missing the next day, which makes Hitoha upset. To cheer her up, Futaba pretends to be a cat, getting a bit too into her roleplay, before Sojirou brings in the cat himself. Later, Yabe comes around the Marui household for a home visit, but as he plays with the cat, Sojirou comes home and misinterprets it as an advance on Hitoha, leading him to get violent against him. Mitsuba wins two tickets and ends up giving them to her siblings, pretending to have other plans. However, it later turns out each ticket admits two people and Mitsuba gets left out, though Sojirou later buys an extra ticket for her.