When Squish's best friend Pod doesn't have time to hang out with him, Squish makes a new friend named Vinny, who seems nice...at first.
When the home puddle of Peggy’s extended family dries up, Squish suggests that she invite them all to stay in Small Pond.
Squish is wrongly accused of stealing Principal Planaria's special box of confiscated student items. In order to prove his innocence, Pod and Peggy must help him “break out” of detention and track down the real thief.
Pod builds a rocket so Squish can get to school on time, but he accidentally crashes the rocket into Principal Planaria, breaking him in half. There are now two Principal Planarias. One is as strict as ever. The other seems groovy and fun.
Pod gets mad at Peggy for always breaking his stuff so Peggy makes a “Powee-Wowee Paramecium Pinky Promise” to never touch anything belonging to anyone ever again.
Genius Pod gets transferred to a special School for Gifted Microbes across Small Pond. He is the first amoeba to attend the school, which is filled with a type of brilliant student bacteria called Paenibacillus Vortex (or “Panny”).
Hygiene-obsessed Pod keeps making his friends late for events with his constant need to stop and clean himself. When Squish and Peggy attempt to cure him of this obsession, their efforts work too well.
Peggy gets kicked out of the school play when Squish accidentally gets cast in her starring role - not for his acting ability, but because he can physically transform himself into the shape of a star.
Squish signs up for Peggy's charity race thinking it's only 27 millimeters long, but it's actually 27,000 millimeters (a huge distance for an amoeba).
Hoping to raise money to buy a special ballcap, Squish and Pod start a pet-sitting business.
Squish resists when his Dad wants to join the garage band Squish has formed with Peggy and Pod. Dad used to be in a band when he was a kid and he offers them plenty of “helpful tips.” Squish keeps dismissing his advice as “uncool.”
High-fashion student Helen the Hydrozoa befriends Peggy and gives her a “makeover” as she tries to turn her into one of her “mean girl” minions.
Squish has a rivalry with the tiny bully Shirley the MicroShrimp, but when an encounter with a pile of salt accidentally shrinks him to her size, Squish must rely on Shirley to show him how to survive as one of the smallest kids in school.
Squish thinks the massive tough-guy student Lynwood is after him so he forms a protective cyst around himself - sort of like a large, round shell.
Due to a unique activity of amoebas, Squish accidentally gets stuck to his best friend Pod like a Siamese Twin.
Pod gets hurt when Squish “lies” to him about an art project. Pod then mixes some glowing substance inside Squish’s cupcakes, making him glow every time he “lies”.
Squish spends all the money his father gave him for supplies on what he thinks is a “gold-making” plant. But the plant only produces poop…which Squish proudly claims is “real” gold, until Pod corrects him.
Helen the Hydrozoa, who has several extra limbs, won’t let Peggy on the cheerleader team because she only has two arms. Squish convinces Peggy to form her own competing team of cheerleaders, filled with an eclectic collection of microbes.
The Algae Brothers mock Squish when he claims the school is being invaded by a monster worm that only Squish has ever seen.
Squish's Dad is looking forward to taking him to a father-and-son Slime Hockey Game, but Squish would rather go to a party with Pod and Peggy.
Helen the mean-girl Hydrozoan threatens to show the school an embarrassing video of Squish unless he agrees to act as her boyfriend so she can make another boy she likes jealous.
When a list of the smartest students in school is posted, Pod is shocked to learn that Peggy ranked higher than him, while they both got the same grades.
Squish, Pod and Peggy arrive at school to find all the students are missing! They soon learn that everyone broke so many rules that Principal Planaria sent them all to detention.
Squish is a big fan of the fictional super-hero, Super Amoeba. While discussing a recent episode of the Super Amoeba TV show with Pod, Squish jokes about saving a baby bacteria like his TV hero.
Vinnie the Virus returns to Small Pond. Squish is wary at first, but Vinny claims that he is only here to help Squish. Vinnie has the ability to make himself look just like Squish, and then do all his chores and schoolwork.
Squish accidentally posts a ridiculous picture of himself on his Germbook page, and the post becomes a huge hit on the site. So Squish posts more absurd images of himself and quickly becomes a social media sensation.