In the first edition, 15-year-old Emily is allowed home for just two hours to decorate the family Christmas tree after having spent almost the entire year in hospital owing to a series of complications relating to a rare genetic condition called Ehlers-Danlos syndrome. Eight-year-old Hya suffered kidney failure at birth, but clotting factors mean that dialysis will not be an option for much longer, so doctors and her family have made the decision that she should have a transplant using a donor kidney from her mother, with Malcolm Lewis carrying out the operation.