Marshal Matt Dillon keeps the peace in the rough and tumble Dodge City.
Matt resigns as Marshall after Tom Samples accuses Matt of killing an innocent man;however, Doc and Matt's old freind Wild Bill Hickok come up with a plan that might clear Matt of this erroneous charge of murder.
After a young man is shot in the back, people think it was young Fly Hoyt. Holly Fanshaw was the only person who saw the murder happen and she tells Matt that Fly Hoyt committed the murder The Older Brother (Joe Thorp)vows revenge for the murder of his Brother. After Holly gives this information to Matt, Matt and Chester set off to bring in Fly Hoyt for murder. After Matt talks to Fly Hoyt, Matt thinks that Fly did not commit the murder and attempts to prove Fly's innocence. Fly gets into this deeper when Holly is shot. Hoyt claims someone shot Holly and the person who shot Holly also knocked Hoyt in the head from behind. Kitty thinks Hoyt is the murderer and can not understand why Matt is supportive of Hoyt. Matt's lawman's instincts and experience determine that Hoyt did not commit these murders. Matt's investigation finally brings him back to Joe Thorp again.
When renegade Pawnee Indians attack some local ranchers, Matt and Major Evans think that white gunrunners supplied the Renegades the rifles. Matt, Chester and Indian scout Tobeel, go the scene of the massacre to pick up the trail of the renegades in the hopes that the Indians will lead them to the camp of the gunrunners. One thing that the gunrunners were not counting on was that the riffles that were sold to the renegades were an outdated Henry 44. Matt thinks that once the Indian renegades find out that they have been cheated and have purchased outdated rifles that no longer have the ammunition in supply, the Indians will go after the gunsmugglers. The Indians do take out revenge on one of the Gunsmugglers, but the other man tries to flee. With the information supplied by a cowboy on the prairie, Matt finally arrives in the camp of the remaining gumsmuggler to confront the man.
Two murders result when an unscrupulous Eastern businessman named Ivy hires a psychotic killer to help him establish undisputed control of Dodge City's freight shipment business.
When Matt is forced to serve an eviction notice on farmer Brandon Teek, Matt tries every way he can to help the farmer. Matt tries to speak with Judge Rambeau in the hope the Judge will stop the eviction process in the proper legal manner. When the Judge refuses to stop the court order eviction of Brandon Teek, Matt refuses to serve the eviction. The Judge hires another man to evict Teek, but the man finds the job of evicting Brandon Teek harder than he ever thought it would be. The man hired to evict Brandon Teek meets resistance from Brandon Teek and a scuffle ensues. Brandon's pregnant wife, Sarah Teek, is injured in the scuffle and loses her child because of the injuries suffered.
Matt and Chester, out of water while riding back to Dodge, come upon a man with two fine horses who is not very trusting. When they meet him later in Dodge, he is much different: friendly and spending money freely.
A stagecoach on which Matt and Chester are riding is robbed and another passenger is murdered. Matt utilizes a ruse to incriminate the thieves when a "cowboy" appears and offers to show him where one of the thieves may be buried.
Matt refuses to arrest his friend Ben Tiple without more evidence, when the man he has been feuding with is found shot in the back.
When a stranger leading some immigrants planning on settling outside of Dodge wants Matt to give him a badge to avert trouble, he gets suspicious and rides out to their camp to see what is really up.
After mild-mannered Hank Blenis is "lynched" by the two men who stole his horse, self-righteous Charlie Drain decides to take the law into his own hands and is led tragically astray by the culprits.
Two gamblers find Matt incorruptible and attempt to intimidate him by hiring gunman Toque Morlan. The two are ironically unaware that Morlan was Matt's close friend until a long-ago attack by a mob left Morlan scarred and harboring a bitter grudge against lawmen.
White men pretending to be Indians attack greenhorn Harry Pope at night, and he kills one of them. Now the dead man's friends want revenge.
Shell Tucker is normally a friendly and peaceful sort of a man. When Shell Tucker's wife swallows a nail, Shell's son (Rufe Tucker) sends for Doc Adams; however, Doc is unable to save Mrs. Tucker from this illness. Since Matt knows that Shell Tucker dislikes Doctors, Matt thinks Shell might try and take the death of his wife out on Doc Adams.. When Doc is shot at on the streets of Dodge, Matt, Chester and Doc ride out to Shell Tucker's farm to talk with Shell. Upon their arrival, they all notice that Shell's horse appears to have a broken leg. Doc believes that it is just a small fracture in the horse's leg and with the placement of a cast, the horse can be saved from being destroyed. Matt tells Shell that he will be arrested for attempted murder unless he agrees to let Doc treat the horse. Several weeks pass when Shell rides into Dodge and confronts Chester. Chester tells Matt and Doc that Shell might be out to get Doc Adams, but when Matt finally confronts Shell Tucker, he finds out
Financially desperate Jack Fitch robs a stagecoach and abducts passenger Laura Church, unaware that she is "engaged" to an unscrupulous businessman who threatened to ruin her father if he did not agree to the marriage.
When two town troublemakers kill Poney Thompson's dog , Poney goes after the two men. When one of the men who shot and killed Poney's Dog is found dead, Matt and Chester suspect that Poney killed the man. Matt is forced to arrest Poney, but as Chester is taking Poney to jail, Poney escapes from Chester Matt, Chester and one of the men who killed Poney's dog (Jed Hakes), go after Poney. Along the trail, Matt and Chester discover Poney dead in a cave from a snakebite wound. Jed Hakes later makes a fatal slip of the tongue and reveals that he killed his partner (Walt Moorman).
Matt's attempt to find a man who shot at him from ambush leads him and Chester into the middle of a murderous feud between two bitter and isolated mountain families.
Over the objections of his sometime partner Rod Allison, treacherous Jim Box murders aging rancher Jesse Wheat, then attempts to steal cattle from Wheat's young widow.
Matt goes along with a hoax when Chester's aging Uncle Wesley arrives for a visit. Wesley thinks Chester is the marshal and Dillion is his assistant.
A man's house is burned and his livestock killed, but he refuses to identify the perpetrators to the marshal.
An old friend of Doc's, a nurse, is visiting and he hopes she will stay around Dodge. In the meantime Matt is worried that an ex-con is gunning for him even though he thought he was innocent five years ago.
Trail boss Dolph Quince sends for his friend Matt to help escort his cattle herd into Dodge because he is having trouble with Jayhawkers (Kansas renegades), and he hopes to ease the animosity his men have towards all Kansans.
An old friend of the family comes to Dodge looking for Kitty, but when he finds out she's a saloon owner, he's dismayed. Intent on defending her honor wherever she is insulted, he nearly gets himself killed. Kitty finally tells him that she has no honor, and he keeps making a fool out of himself thinking otherwise. It sends him away and saves his life at the same time.
While Chester is teaching Miss Kitty guitar playing and singing technics, the cowpokes at the Long Branch are making quite a fuss over Frog mouth Kate. Kate has a fondness for a younger man almost half her age (Billy Daunt). Billy does not share the same feelings for Kate and runs away much to the delight to the Long Branch barflies. Late that night, Chester wakes Matt in the middle of the night to tell Matt that Kate had been shot at Ma Torvet's boarding house. Ma Torvet tells Matt that Billy was the one who shot Kate. Ma also believes that Billy shot Kate because Kate kept some money stashed away under her bed. Matt and Chester search the countryside for Billy Daunt. While Matt and Chester are conducting their search, they discover the wife of a destitute farmer who claims Billy killed her husband and tortured a very old man. Matt and Chester finally overtake a desperate Billy Daunt and transport Billy back to Dodge. Shortly after their arrival in Dodge, Matt finds out some more tro
When another Doctor shows up in Dodge promising lower Doctor's fees and miracle cures, Doc gets angry and and many Dodge citizens think Doc Adamas has quit as Dodge's doctor. When Doc comes up missing, Matt looks for Doc and finds him fishing outside of Dodge. Doc tells Matt that he thinks the new Doctor is nothing but a quack. Doc Adamas believes the new Doctor is a quack. Doc's beliefs are later proven to be true when the new Doctor's medical treatments amost kill a young boy.
Rivalry for the affections of a former saloon gal leads to a frame-up for murder.
A coward gambler, who's too cheap to hire a gunman, wants Matt dead for a beating he got from him years ago, so he starts some talk around Dodge about the big reputation any person could gain, if they simply killed Matt.
When Onie Becker is shot down on the streets of Dodge after quarreling with Al Clovis in a poker game, everyone thinks Al Clovis committed the shooting. The plot thickens after Matt and Chester pursue Clovis on a train headed out of Dodge.
Men start killing each other over saloon girl Dolly Varden, who seems to bring gamblers luck just by standing next to them when they're playing cards.
After years of captivity, a white woman and her half-Indian daughter are set free by the Indians, but they are shunned in Dodge.
A gunfight in the Long Branch forces Matt to arrest a drunk. Letting him go since it was a fair fight, he suspects him of selling guns to the Indians, and goes after him even though he may run into those Indians.
Matt and Dodge City's businessmen employ an unusual tactic to save ambush victim Lee Prentice from being taken to corrupt Baker City to face certain hanging on a trumped-up murder charge.
Matt becomes suspicious when Jerry Cass's plans to marry saloon hostess Bella Grant are complicated by Bella's sudden insistence that Jerry leave his recently-inherited ranch for six months.
When a Buffalo hunter dies from injuries from burning led, Matt and Doc think that their boss (Jim Gatluf) might have had something to do with the man's dying. After Matt speaks with one of Gatluf's employees about the killing of the Buffalo skinner, Matt is convinced that Gatluff murdered the man. Soon after, Chester informs Matt that another Buffalo skinner had been murdered. Since Matt is now convinced without any doubt that Guttliff committed these murders, Matt and Chester set off to bring Gattluff in for murder. While Matt and Chester are searching for Gatluff out on the prairie, they run into a buying agent who tells Matt that he had recently done business with Gatluff. The agent also informs Matt where Gatluff's is. When Matt and Chester ride into Gutluff's camp, they discover another one of Gutluff's men who has been attacked by Guttluf with a knife. Matt and Chester finally find Guttluff's camp, but soon discover some more troubling information about this case.
Matt tries to help Andy Hill, a young gunman who is apparently trying very hard to go straight, by getting him a job riding shotgun on the stagecoach.
Gunman Kin Creed arrives in Dodge determined to enhance his reputation by outdrawing Matt in a gunfight. He goes to great lengths to force Matt into a confrontation and is able to wound him, but it proves to be a pyrrhic victory.
Print Asper is suspected of attempted murder when he forces a crooked lawyer, at gunpoint, to return the ranch he stole from him, and the lawyer still ends up getting shot later by someone.
Dodge City's businessmen learn a hard lesson when they reject Matt's advice and hire a meek constable to handle a gang of rowdy but free-spending trail cowboys.
Seriously injured Matt faces a moral dilemma when Blue Horse saves his life and prevents the escape of a prisoner. The Marshal knows that Blue Horse is being sought by the Cavalry as a fugitive from a reservation, and he is well aware that he is duty-bound to assist their search in any way possible.
Matt seeks the help of wise Chief Long Robe to track down gunrunners who are supplying renegade Cheyenne braves with rifles used to murder prairie-dwelling families. Long Robe provides Matt with the needed information, but warns him that the death of even a single brave could lead to a violent uprising.