Drifter Jess Harper arrives in Laramie searching for a man, but gunfire sends him out into the countryside, where he meets rancher Slim Sherman and his brother, Andy.
A down-on-his-luck drifter with ties to Jess arrives at the Sherman station with a lady preacher; though Jess tries to avoid the man, events force Jess to become involved.
Martha Chambers takes refuge from vengeful Indians at the Sherman ranch after she kills the son of a Pawnee chief in a moment of blind terror.
Gil Brady seeks out help from his brother-in-law, Jess Harper, when he deserts the calvary and heads for Canada.
Tully Hatch, the man who saved Jess Harper's life and later made him a deputy sheriff, has been accused of robbing a bank and Jess feels he must help him.
Jess takes on an undercover job for the sheriff, acting as a guide for an outlaw who's searching for money stolen in an earlier robbery.
Slim and Jess capture an outlaw and his partner, but find the tables turned when the outlaw's gang breaks the pair out of jail during the trial.
A beautiful but greedy rancher's wife turns to old friend Jess for help in leaving her rich husband, but her husband has sent bounty hunters after her.
A gunfighter comes to Laramie and picks up his mail in care of GENERAL DELIVERY to see who he has been hired to kill.Jess knows him and confronts him to see who he was hired to kill.He is injured on the Sherman ranch and Andy tries to reform him.
Slim's old war buddy arrives on the stage, ostensibly for a visit, but his real intent is to assassinate General Sherman.
Jess is livid when his innocent friend is tried, convicted and hanged for the murders of Doc Webb and Sheriff Kiley.
A priest tries to arrange a meeting with Sitting Bull to talk about a peace treaty.
After a run-in with a traveling prizefighter leaves a mess at the station, Jonesy becomes the man's promoter to help pay the bills at the station.
Slim gets a threatening letter, addressed to his late father, from a man who wants vengeance for the death of his son.
While Jess is away, Slim leases a rough section of land to a former lawman who, unbeknownst to Slim, has hired a bunch of outlaws as his ranch hands.
Wyoming Territory has become the winter battleground for the warring Sioux and Cheyenne, forcing Slim and Jess to close the ranch and relay station.
After a drought and the ending of the stage line, Slim and Jess must join a cattle drive run by a stranger who at first seems impressive, but soon their suspicions are aroused.
When Jess serves as a special deputy to transport a man who's accused of killing his wife, the stagecoach is attacked by a group that's looking for the prisoner
Aging but beautiful Lily Langford is touring the West, and she arrives in Laramie broke and one step ahead of bill collectors, thanks to her gambler husband.
Passengers of a stagecoach, forced to wait out a storm at the Sherman Ranch, all have something they are trying to hide.
The new stage line superintendent wants Jess fired, which causes tension on the ranch; Slim and Jess track horse thieves.
A man interrupts a murder and robbery, and makes the most out of his moment of celebrity at Slim's expense.
Jess unwillingly works to help T.J. Patterson track a thief who stole money from the stage line, along with the heart of Patterson's daughter.
Five years after committing murder, Frank Buckley is paroled to Slim Sherman, but there are some in town who don't want the killer in their midst.
Slim and Jess hunt for Vernon Kane, who has robbed the bank and killed a popular deputy, but their search also leads them to a gambler and his wife, who've joined forces with the outlaw.
Slim and Jess join a posse hunting for three escaped gang members who attempted to rob the Wells Fargo office, killing a deputy sheriff.
Slim and Jess become involved in a fight between the ranchers and the homesteaders, and despite their efforts at keeping the situation under control, a rancher is murdered.
Hoping to find a better price for their cattle, Slim and Jess wind up in Nebraska, where the death of the marshal leads the two to take his place for a month.
Jess, on the run after killing a marshal, is offered a place in Owen Cantrell's private army fighting in a border dispute between the U.S. and Canada.
Slim encounters a loudmouthed bully with a wagon train on the outskirts of town, and when the bully is killed, Slim is kidnapped to face charges of murder per the wagon train rules.