Teresa Mendoza, is a woman who is forced to run and seek refuge in America after her drug-dealing boyfriend is unexpectedly murdered in Mexico. In the process, she teams up with an unlikely figure from her past to bring down the leader of the very drug trafficking ring that has her on the run.
The Mexican drug cartel comes after Teresa, forcing her on the run.
Teresa has to prove her worth to Camila. Meanwhile, Epifanio gets closer in his hunt for Teresa. Back in Mexico, Brenda desperately tries to find Teresa and hide from the cartel.
Camila sends Teresa out on a major drug operation to test her loyalty. In secret, Camila makes her first big move to take over Epifanio’s cartel. Meanwhile, Brenda plots her escape to America.
A deadly mistake mars Teresa’s first solo drug run and she soon finds herself in peril. Meanwhile, Brenda and Tony make the risky escape to Dallas.
Teresa witnesses a horrific event that forces her to advance her plans. Now, safely in Dallas, Brenda needs money to survive, and starts assembling a rag tag team to help her sell drugs.
Camila, riddled with debt and short on supply, grows desperate and ponders giving Teresa up. Meanwhile, Brenda's burgeoning drug enterprise creates a rift between her and Tony.
Camila sends Teresa out on a life-threatening, multi- million dollar midnight mission. Pressured by a lack of supply, Brenda puts her crew in the line of fire.
A desperate Camila attempts an incredibly risky heist. Meanwhile, Teresa goes undercover and, with her life on the line, is forced to make a choice that forever changes her.
Teresa races to save a witness in the recent heist. With renewed confidence, Camila assures her partners that she’s back in business and vows to be done with Epifanio once and for all.
Camila returns to Mexico to protect her life, while James hunts Teresa down. Meanwhile Teresa finds herself in grave danger taking Maria through the tunnel to Mexico.
Aligning with the Jimenez Cartel, Camila’s operation goes underground. Teresa and Brenda try to start a new life utilizing knowledge from Güero’s book.
Teresa and Brenda risk everything in a game of extortion. Camila takes further steps to overtake Epifanio’s empire.