A glimpse into an alternate history of North America: what life after WWII may have been like if the Nazis had won the war. The Man in the High Castle explores daily life in 1962, fourteen years after the end of a longer Second World War (1939–1948 in this history). The victorious Axis Powers - Imperial Japan, Fascist Italy, and Nazi Germany - are conducting intrigues against each other in North America, specifically in the former U.S., which surrendered to them once they had conquered Eurasia and destroyed the populaces of Africa.
Joe returns to New York to hand over the film to Smith and request for his resignation, but Smith denies his request before delivering the film to Hitler. Karen and Lem confront Juliana for not shooting Joe before she is tranquilized. She wakes up in the home of Hawthorne Abendsen, The Man in the High Castle, and his vast film collection. Meanwhile, General Onoda reveals to Tagomi and his staff that the capsule Science Minister Shimada found in his pocket contains the plans for a nuclear weapon that the Empire intends to use to crush the Nazis, much to Tagomi's dismay. Frank confronts Arnold about spying over his own family. Desperate to clear Ed's name, Frank goes to Childan and asks for his help. Juliana attempts to get answers from an evasive Abendsen and receives a clue which may help to avert nuclear war. Gary Connell, leader of the West Coast Resistance, goes against orders and tries to kill Juliana, but she escapes at a Kempeitai checkpoint. A gunfight ensues between the Resistance members and the Japanese soldiers. Karen is killed in the crossfire.
After narrowly escaping death, Juliana discovers a family secret that could have global implications - and leads her to make a life-changing decision. Kido, Tagomi, and Frank all take dangerous risks, while back in New York, Joe settles into a normal routine, only to have it turned upside down when Smith gives him the opportunity he's waited for his whole life.
Fighting to acclimatize to the strange new world of Nazi New York, Juliana seeks out the one person she thinks she can trust: Joe Blake. Angry and defiant after Juliana's departure, Frank is drawn to the Resistance movement and its charismatic leader. Joe confronts his own identity when he finally meets his father.
Juliana discovers she's far from safe from the Resistance in the Reich. Smith confronts the reality of the lengths he's willing to go to in order to protect his son. And another father - Joe's - tries to persuade him to give Berlin a chance. Frank also has a decision to make: how far is he prepared to go to help the Resistance cause?
Joe learns a truth about his past that makes him question everything. The rift between Frank and Ed widens as Frank is drawn further into the Resistance. In order to assure her safety, Juliana must betray someone close to her.
Nicole introduces Joe to an unexpected side of Berlin, that leads him down a new path. On her new mission, Juliana inserts herself into the Smith's inner circle. Tagomi is finally reunited with his family, only to be faced with the prospect of losing them again.
As Juliana worms closer to the Smiths, she discovers a dangerous secret. Childan and Ed get themselves in a sticky situation as they try to settle the Yakuza debt. On a Resistance mission, Frank uncovers a Japanese plan that could realize his worst nightmare.
Juliana gathers intel for the Resistance that could trigger WWIII. When the political situation in Berlin becomes unsafe, Joe must make a choice that could put his life in danger. Frank learns the truth about Juliana, leading him to question his newfound Resistance family.
Tagomi faces a dilemma: to stay with his family or return to the world he left behind. Desperate to escape the Reich, Juliana strikes a final, dangerous deal with the Resistance. When Ed reveals a secret that puts the Resistance plan in jeopardy, Frank must decide how to deal with his best friend's betrayal.
Tagomi enlists Kido in a deception to save Japan from destruction. As Smith's life crumbles around him, he makes a dangerously bold play to hold onto his power. Joe tries to do the right thing but suffers the ultimate betrayal. Juliana must make a heart-wrenching choice that will shape the future of the world.