Red vs. Blue centers on the Red and Blue Teams, two groups of soldiers engaged in a civil war. Each team occupies a small base in a box canyon known as Blood Gulch. According to Simmons (Gustavo Sorola), one of the Red Team soldiers, each team's base exists only in response to the other team's base. Although both teams generally dislike each other and have standing orders to defeat their opponents and capture their flag, neither team's soldiers are usually motivated to fight each other- if they are otherwise, neither are efficient. Teammates have an array of eccentric personalities and often create more problems for each other than for their enemies.
In an unknown location, Washington is heard creating a journal entry. Admitting that it has been a while since doing one, Wash decides to get up to speed: he recalls the corruption of Project Freelancer, its demise, his job as a Recovery agent, and Project Freelancer's misuse of the Reds and Blues as cannon fodder for their Freelancer agents. The only people Wash could trust was the Reds and Blues and together, they succeeded in bringing down Project Freelancer and the Director once and for all. Wash then mentions the fact that they became shipwrecked while on their way home, and fears that if help doesn't come soon, someone else may find them.
Wash talks to the group - Comm tower S11
Finishing his entry, Wash hears the tank fire and sees that Sarge and Simmons are using it on their own base, with Grif still inside. Wash asks why Sarge has the tank, but quickly realizes Caboose gave it to the Reds. Sarge says that he's renovating their base, and also mentions the Blues' unfair advantage, due to the fact that their base lies under the crashed ship. Wash informs the group that they all need to ration their food supply, as they need to repair a communications dish to call for help before they run out of food. Afterwards, Caboose and Wash take the tank back to their base, in order to have a word with Tucker.
Wash and Caboose leave for Blue base to confront Tucker. Meanwhile, the Reds discuss a dilemma about their base.
Sarge lays down a few ground rules regarding his personal space, while Wash comforts a sad Caboose.
While depressed over the departure of his best friend, Caboose comes across something mysterious.
As Washington and Tucker begin work on the communications tower, Sarge activates Red Team's newest addition.
The Reds and Blues work together to repair the communications tower. Afterwards, Caboose introduces his new friend.
The Blues get acquainted with Caboose's robotic pet Mantis, Freckles. Meanwhile, Sarge orders Grif and Simmons to recon on Blue Team.
Grif and Simmons execute their reconnaissance on Blue team.
Sarge overreacts over Simmons' departure and prepares a counterattack. Meanwhile, Washington and Tucker butt heads.
Tensions arise between the Red and Blue teams.
While Caboose gets accustomed with his new position, the Reds divulge a plan to eliminate Freckles.
Sarge, Grif, and Doc discover some interesting things inside the ship.
Simmons brings a source of social media to the canyon, while Lopez and Lopez 2.0 are given important information.
Donut cleans the Red base, while Wash and Tucker have a discussion over leadership.
Wash gives Caboose a present, while the Reds complete their construction on their Mantis.
Felix, the orange soldier, tells the Reds and Blues about where they landed and why it was so important for him to find them.
The Reds and Blues begin fortifying their defenses for an imminent attack. Meanwhile, Lopez 2.0 gets a dastardly plan.
The Reds and Blues engage in a fierce battle against Locus and the Federal Army.