Red vs. Blue centers on the Red and Blue Teams, two groups of soldiers engaged in a civil war. Each team occupies a small base in a box canyon known as Blood Gulch. According to Simmons (Gustavo Sorola), one of the Red Team soldiers, each team's base exists only in response to the other team's base. Although both teams generally dislike each other and have standing orders to defeat their opponents and capture their flag, neither team's soldiers are usually motivated to fight each other- if they are otherwise, neither are efficient. Teammates have an array of eccentric personalities and often create more problems for each other than for their enemies.
The infiltration of a mining facility goes haywire for the New Republic.
Felix and Tucker take a group of Republic soldiers to blow up a Federal Army outpost.
Kimball makes a deal with the Reds and Blues to assemble a small team in five days to go rescue their friends before they are moved to the capital.
The Reds and Blues run into problems while forming their elite rescue team.
The Reds and Blues begin their training with their chosen recruits.
Kimball talks to Tucker about Felix's past and his connection to Locus.
The Reds and Blues begin their rescue mission ahead of schedule without the recruits.
The Red and Blue captains arrive at the compound and attempt to break in.
Weeks before their encounter with their friends, Wash, Sarge, Donut, and Lopez discover the Federal Army of Chorus' true intentions.
Together once again, the Reds and Blues learn the truth about Chorus' conflicting factions and come up with a solution to end the war. However, they are unexpectedly attacked.
Weeks before rescuing their friends, Carolina and Epsilon infiltrate an F.A.C. Munitions Plant in order to obtain data from a team of mercenaries.
Now reunited, Carolina and Epsilon inform the Blood Gulch Crew on the Mercenary team and the group plan out their next move.
The Blood Gulch Crew further analyze the manufactured alien tech.
The Blood Gulch Crew search the two halves of the UNSC ship at crash sites Bravo and Alpha.
After nearly being ambushed by a space pirate, the Blood Gulch Crew interrogate the enemy.
The Federal Army of Chorus and the New Republic prepare for their upcoming battle.
The Reds and Blues ponder on whether to accept Felix and Locus' deal. Meanwhile, the New Republic infiltrate Armonia.
The Blood Gulch Crew take on the Space Pirates, while the Federal Army and the New Republic battle it out.
After having the Feds and Rebels come to a truce, the Blood Gulch Crew uncover the secret behind the identity of Control.