Kirsten is recruited into a covert government agency to be 'stitched' into the minds of the recently deceased, using their memories to investigate murders and decipher mysteries that otherwise would have gone to the grave. Working alongside Kirsten is Cameron, a brilliant neuroscientist whose passion for the program is evident in his work. The secret program is headed by Maggie, a skilled veteran of covert operations, and includes Linus, a socially immature bioelectrical engineer and communications technician. Kirsten's roommate, Camille, a gifted computer science grad student, is also recruited to use her skills to assist Kirsten in her new role as a 'stitcher.'
Kirsten successfully revives Cameron, but finds that stitching into a live consciousness is now causing her to experience real emotions for the first time.
When a hacker is found dead, the team learns he blackmailed an Ashley Madison-like website and threatened to release their client list online
When Fisher's mentor turns up dead, Kirsten's stitch reveals the officer was murdered by a serial killer she's been chasing for years. The Stitchers team picks up the detective's leads in an effort to finally bring the suspect to justice, but danger arrives in an unexpected form when Cameron is trapped with the killer. Camille's rebellious older brother Theo arrives in town with a whole lot of trouble. Meanwhile, Cameron is finally honest with Kirsten about his feelings for her.
When an unidentified, severely damaged body is recovered in a dumpster, Kirsten’s stitch divulges that the victim has two death scenes from two very different times in his life. When it’s clear the victim had valuable information that could put a lot of people in danger, the team’s investigation leads them to Dr. Naomi Burke, a physicist with a hidden agenda. Camille tires of her brother Theo’s irresponsible ways and finally puts her foot down. Meanwhile, Linus turns to Cameron for help with a sticky situation and Detective Fisher and Kirsten uncover a clue about her father.
When a young woman falls to her death with a cryptic note attached to her body, Kirsten is convinced the message is somehow tied to her own past. But when the stitch reveals the victim was brainwashed to kill movie director Roman Bain, the team ends up in a race against time to find the person responsible before someone gets seriously hurt. Meanwhile, Camille’s defense training unexpectedly reunites her with Liam
After a Chinese pop star is murdered, her bodyguard Mei Ling is accused of negligence in letting the crime happen. But when Kirsten stitches in, she realizes the bodyguard was poisoned before the singer died. The team now has to race against the clock to find the murderer before Mei Ling is sent back to China to face charges. Kirsten has to answer questions from her friends about her obsession with finding Daniel Stinger, but finally makes progress on her search. Meanwhile, Cameron is nervous when Kirsten tells him she wants to meet Nina, and Camille continues to cross paths with Liam.
When a bright, young lawyer is found dead, the team suspects she was murdered because of a case she was working on. After theorizing the lawyer was killed because she discovered something criminal about her firm's high profile client, the team heads to the firm to interview her four ambitious coworkers, each of whom seems more suspicious than the last. While at the firm, Maggie crosses paths with a former college boyfriend (guest star Dondre Whitfield, "Mistresses") who may be closer to the murder than she'd like to admit. Meanwhile, Camille's interactions with Liam take a surprising turn, and Kirsten learns something shocking during the stitch.
The Stitchers team goes into overdrive when a plane lands in Los Angeles with multiple dead passengers and no apparent cause. Now racing against the clock to determine if this is a terrorist attack or the work of a fellow passenger, Kirsten is tasked with stitching into one victim after another to learn exactly what happened. Cameron worries about Kirsten's well-being and their new dynamic in light of his relationship with Nina. Meanwhile, Camille tries to help Linus through a personal issue, and Liam continues to cause problems.
Mitchell Blair directs Kirsten to shut down all investigation into finding her father. But Kirsten has finally made contact with someone she thinks can lead her to him. To gain her source's trust, she tries to explain her role in the Stitchers program, without actually revealing the program's nature. Treading carefully, Kirsten recounts the team's current case, in which a series of murders is tied to a wildly popular new app.
Kirsten is angered by Liam’s treachery, but before she can find her father to seek answers, he disappears. She searches for information, but gets more than she bargained for when she discovers a shocking family secret. Now Kirsten finds herself heading down a dark and dangerous path into her own memories to seek the truth – at any cost.